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Old 05-21-2012
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Drug Tamoxifen for HRT

Forgive me if this sounds stupid,

but considering tamoxifen offers all benefits of Hormone replacement therapy, why cant we use Tamoxifen for HRT? it will reduce breast cancer risk too, right?
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Old 05-21-2012
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Originally Posted by tarsuc View Post
Forgive me if this sounds stupid,

but considering tamoxifen offers all benefits of Hormone replacement therapy, why cant we use Tamoxifen for HRT? it will reduce breast cancer risk too, right?
Perhaps because it is not FDA approved for that use, I don't know.
Have you researched the research done on these lines? Why don't you research it and enlighten us. It will help us all. Thanks.
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got it. Its because tamoxifen has a side effect of causing hot flashes occasionally. Will defeat the purpose if used for HRT.
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Old 05-21-2012
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Tamoxifen can also cause endometrial hyperplasia, cos it acts as a partial agonist on endometrium.(please correct me if i am wrong!)
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yea. partial agonist premenopausal women and complete agonist post menopausal women as far as endometrium is concerned. I'm not sure.
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Old 05-22-2012
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Hi, Tamoxifen as a partial agonist is indicated only for ER positive breast cancer, in post menopausal women it works as partial agonist in the endomatrium- causes hyperplasia and risk of endometrial carcinoma.

Raloxifen is a drug that can be used as treatment for osteoporosis in postmenopausal women - according to the drug companies although it's also a partial agonist of estrogen receptors, it acts as antagonist in the endomatrium (logic says it's fishy, but lets wait and see).

Raloxifen also acts as antagonist in breast cancer, but it's not it's indication.

Both of the drugs act as agonist in the bones so both of them can be used, but tamoxifen is not used due to the risk of the endometrial carcinoma.
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Old 05-25-2012
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Wouldnt tamoxifen be a complete agonist in post menopausal women, as there is no endogeonous estrogen at all, and a partial agonist in pre menopausal women, as estrogen is present?
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Old 05-26-2012
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Originally Posted by tarsuc View Post
Wouldnt tamoxifen be a complete agonist in post menopausal women, as there is no endogeonous estrogen at all, and a partial agonist in pre menopausal women, as estrogen is present?
Anyhow, it still increases the risk of endometrial cancer!

Tamoxifen and Raloxifene both are antagonists in the breast and agonists in the bone.

But Tamoxifen is an agonist in the endometrium whereas raloxifene is an antagonist.

SO in post-menopausal women who DO have a uterus, raloxifene is a much better option whereas tamoxifen may be given to women who do not have a uterus!
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