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Old 06-06-2016
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Star explanations

please can someone explain why barbiturates are contraindicated in porphyrias?
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Old 06-06-2016
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Barbiturates are P-450 enzyme inducers...& when we say induce,they act at gene level & increase the gene expression of P-450....which means more enzymes are synthesized....& P-450 enzymes have a heme grp in them...therefore heme synthesis is also stimulated.And as u know,in porphyrias,there is a def of the porphobilinogen deaminase...so when heme synthesis is stimulated,more of the substrates porphobilinogen,delta-ALA are gonna accumulate & worsen the porphyria.

Hope this helps.
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Old 06-07-2016
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thanks a lot.. it makes so much sense now....
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