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Old 05-22-2012
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Question Deafness, Ocular Abnormalities, And Nephritic Syndrome Diagnosis

A clinical study is performed on young male with deafness, lens dislocation, cataract, and nephritic syndrome. Kidney biopsy of these subjects reveal no pathology under immunofluorescence or light microscopy. Which of the following should be a defect in this patient?


A) Mutation in the gene for α1-chain of collagen type IV
B) Mutation in the gene for α2-chain of collagen type IV
C) Mutation in the gene for α3-chain of collagen type IV
D) Mutation in the gene for α4-chain of collagen type IV
E) Mutation in the gene for α5-chain of collagen type IV





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Old 05-22-2012
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D...........................?
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Old 05-22-2012
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D as I think
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correct answer is E
hereditary glomerular disease-
alport's syndrome,autosomal dominant disease,x-linked recessive,autoantibodies to tipe IV collagen in GBM
no specific immunofluorescence or electron microscopic findings
sensorineural hearing loss and ocular abnormalitis
defective GBM synthesis due to mutations in a5 chain of collagen IV,associated form with diffuse leiomyomatosis has additional mutation in a6 chain
golgan rr 88, 404 pg
http://www.pathologyexpert.com/board.../syndromes.htm
FA(2012)-84, 516 pg

Last edited by irakly; 05-22-2012 at 07:01 PM.
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Old 05-22-2012
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F).................
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Originally Posted by DocSikorski View Post
F).................
F) is not one of answer of choice man!
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Originally Posted by alfjof View Post
F) is not one of answer of choice man!
F is always an option.

"F" is for *uck!!

I would bet a hundred bucks that 99.99% of people who are being asked this question would never know the right answer.

Even Goljan writes a 3,4 or 5 chain in Alport disease.

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btw man, check yer motto - there is letter "R" in the word "Learn"
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the answer is C
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Originally Posted by DocSikorski View Post
F is always an option.

"F" is for *uck!!

I would bet a hundred bucks that 99.99% of people who are being asked this question would never know the right answer.

Even Goljan writes a 3,4 or 5 chain in Alport disease.

============

btw man, check yer motto - there is letter "R" in the word "Learn"
Come on man don't be upset with the question, simply is USMLE
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  #10  
Old 05-22-2012
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was looking thru the answer choices to find type 4 collagen...sees all are type 4 collagen
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  #11  
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Originally Posted by DefeatTheBeast View Post
was looking thru the answer choices to find type 4 collagen...sees all are type 4 collagen
Looks like you've found em! =)
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the answer is C
i agree...its the alpha 3 chain of type 4 collagen
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  #13  
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Goljan RR says (3,4 or 5 ) , so which one is it?
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A) Mutation in the gene for α1-chain of collagen type IV
B) Mutation in the gene for α2-chain of collagen type IV
C) Mutation in the gene for α3-chain of collagen type IV: Goodpasture's syndrome
D) Mutation in the gene for α4-chain of collagen type IV
E) Mutation in the gene for α5-chain of collagen type IV: Alport's syndrome: X-linked & Mutation genetic for α5-chain of collagen type IV(correct answer)
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hey, whats the source of the question?
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Originally Posted by DocSikorski View Post
hey, whats the source of the question?


USMLERX
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  #17  
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USMLERX
Wow.
Doin rx these days, never say anything as cray as this
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Quote:
Originally Posted by alfjof View Post
A) Mutation in the gene for α1-chain of collagen type IV
B) Mutation in the gene for α2-chain of collagen type IV
C) Mutation in the gene for α3-chain of collagen type IV: Goodpasture's syndrome
D) Mutation in the gene for α4-chain of collagen type IV
E) Mutation in the gene for α5-chain of collagen type IV: Alport's syndrome: X-linked & Mutation genetic for α5-chain of collagen type IV(correct answer)
Lol, same guy with his bullshit questions. Every time I check these boards... without fail.
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Originally Posted by DocSikorski View Post
Wow.
Doin rx these days, never say anything as cray as this


You have to be waiting and reading with careful the explanation they give you
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Lol, same guy with his bullshit questions. Every time I check these boards... without fail.
wow dude, calm down!
these questions are not BS.
Way off and too hard maybe but not bs
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Lol, same guy with his bullshit questions. Every time I check these boards... without fail.

The next time you see my questions in this forum give them 2 favors plz: CLOSED YOUR F*** EYES & YOUR f***** MOUTH IF YOU NOT KNOW THE ANSWER BECAUSE IS NOT AN OBLIGATION
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wow dude, calm down!
these questions are not BS.
Way off and too hard maybe but not bs
That's exactly what I mean though. The questions that he posts are completely off topic and irrelevant for Step 1. Maybe they're pertinent for Step 2 or Step 3, but these are Step 1 forums.

Somebody like you, for example, have a pretty good grasp of what's going to be tested on Step 1. You know, for example, that the questions he asks are indeed "way off" and "too hard". But have you considered how many other lurkers are out there, stumbling onto these forums, and reading these threads? Imagine if you didn't know any better, and you came across a question like this. To what purpose would it serve? Would it teach you anything remotely useful for Step 1? No. Would it freak you out and make you doubt yourself and your studying methods? Quite possibly.

What really irks me is that it's not even that he's posting these questions because he's not sure of the answer, or because he wants to start a healthy discussion. He posts these as "quizzes", and then when people inevitably get them wrong and say that they're too detailed, he responds like this:

Quote:
Originally Posted by alfjof View Post
You have to be waiting and reading with careful the explanation they give you
I'm not actually sure exactly what that means, but my interpretation was something to the effect of "if you had read through your materials more carefully then [you should] be able to answer questions like these", which sends a completely wrong message.

I've seen you post around here, Doc, and I respect you as well as the quality of your posts. That's the only reason I'm giving this explanation.
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Originally Posted by johndoe3344 View Post
That's exactly what I mean though. The questions that he posts are completely off topic and irrelevant for Step 1. Maybe they're pertinent for Step 2 or Step 3, but these are Step 1 forums.

Somebody like you, for example, have a pretty good grasp of what's going to be tested on Step 1. You know, for example, that the questions he asks are indeed "way off" and "too hard". But have you considered how many other lurkers are out there, stumbling onto these forums, and reading these threads? Imagine if you didn't know any better, and you came across a question like this. To what purpose would it serve? Would it teach you anything remotely useful for Step 1? No. Would it freak you out and make you doubt yourself and your studying methods? Quite possibly.

What really irks me is that it's not even that he's posting these questions because he's not sure of the answer, or because he wants to start a healthy discussion. He posts these as "quizzes", and then when people inevitably get them wrong and say that they're too detailed, he responds like this:



I'm not actually sure exactly what that means, but my interpretation was something to the effect of "if you had read through your materials more carefully then [you should] be able to answer questions like these", which sends a completely wrong message.

I've seen you post around here, Doc, and I respect you as well as the quality of your posts. That's the only reason I'm giving this explanation.
Nobody in this forum will say you how this exam is, the only thing I can tell you 40% of the test it will look like this with a lot of thing to confuse you with the diagnosis deferential in each answer of choice. I recall you again when you see my post in this forum don't read it if you think is a wrong MSG ok
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Old 05-23-2012
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Quote:
Originally Posted by johndoe3344 View Post
That's exactly what I mean though. The questions that he posts are completely off topic and irrelevant for Step 1. Maybe they're pertinent for Step 2 or Step 3, but these are Step 1 forums.

Somebody like you, for example, have a pretty good grasp of what's going to be tested on Step 1. You know, for example, that the questions he asks are indeed "way off" and "too hard". But have you considered how many other lurkers are out there, stumbling onto these forums, and reading these threads? Imagine if you didn't know any better, and you came across a question like this. To what purpose would it serve? Would it teach you anything remotely useful for Step 1? No. Would it freak you out and make you doubt yourself and your studying methods? Quite possibly.

What really irks me is that it's not even that he's posting these questions because he's not sure of the answer, or because he wants to start a healthy discussion. He posts these as "quizzes", and then when people inevitably get them wrong and say that they're too detailed, he responds like this:



I'm not actually sure exactly what that means, but my interpretation was something to the effect of "if you had read through your materials more carefully then [you should] be able to answer questions like these", which sends a completely wrong message.

I've seen you post around here, Doc, and I respect you as well as the quality of your posts. That's the only reason I'm giving this explanation.

Sure thing. I think these questions are irrelevant for Step I too.
Completely agree dude
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Actually i find his posts useful
I think the question stem is more important to refresh info on alports syndrome than the correct option


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  #26  
Old 05-23-2012
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Though these wouldn't be the type of Qs in actual exam(I pray they won't be :sorry

few af them help to know new things, refresh knowledge build connections and how worst could be the Qs.. He says few are from USMLE Rx so they are not made up either.. He at least cares to share ..

I just go through them take whatever I can and if they are way over my head I would be like whatever
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  #27  
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Quote:
Originally Posted by johndoe3344 View Post
That's exactly what I mean though. The questions that he posts are completely off topic and irrelevant for Step 1. Maybe they're pertinent for Step 2 or Step 3, but these are Step 1 forums.

Somebody like you, for example, have a pretty good grasp of what's going to be tested on Step 1. You know, for example, that the questions he asks are indeed "way off" and "too hard". But have you considered how many other lurkers are out there, stumbling onto these forums, and reading these threads? Imagine if you didn't know any better, and you came across a question like this. To what purpose would it serve? Would it teach you anything remotely useful for Step 1? No. Would it freak you out and make you doubt yourself and your studying methods? Quite possibly.

What really irks me is that it's not even that he's posting these questions because he's not sure of the answer, or because he wants to start a healthy discussion. He posts these as "quizzes", and then when people inevitably get them wrong and say that they're too detailed, he responds like this:
true that.
anyway thats his opinion on what is step 1... Any opinion has a right to be expressed.
It actually took me a while to understand what "study smart" means and what is a good and fair question.
I believe that you really know the topic when you can make a good question from it.
Not a question that no one except u or another person with a technician book on hand or any other book that u were reading before coming up with this unfair question can answer. But a question that contains all the nice clues and the quality description of a syndrome and asks you relevant piece of information that u, as a doctor, have to know.

I believe alfjof is a good guy that digs his way through these piles of crap that USMLE puts in front of us, maybe with a poor and confusing english though.
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  #28  
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true that.
anyway thats his opinion on what is step 1... Any opinion has a right to be expressed.
It actually took me a while to understand what "study smart" means and what is a good and fair question.
I believe that you really know the topic when you can make a good question from it.
Not a question that no one except u or another person with a technician book on hand or any other book that u were reading before coming up with this unfair question can answer. But a question that contains all the nice clues and the quality description of a syndrome and asks you relevant piece of information that u, as a doctor, have to know.

I believe alfjof is a good guy that digs his way through these piles of crap that USMLE puts in front of us, maybe with a poor and confusing english though.
johndoe3344: <same guy with his bullshit questions>; he crossed the line telling me that thing, sorry for my bad word I post was not my intention guys.
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