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  #1  
Old 05-23-2012
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Question Fertility Should Be Caused By Which Of The Following

a 28-year-old woman with a history of recurrent upper respiratory infections(URIs) presents to your clinic with her fifth URI in the past month. she mentions that she may be getting sick due to increased stress at home; she and her husband have been trying to conceive unsuccessfully for about 4 years. the laboratory study shows everything within normal limits. Which unit represents the structure most likely to be defective in this patient?


A) Collagen alpha chains in triplets
B) Central pair with nine peripheral pairs of microtubules
C) Autosomal recessive defect in CFTR genes on chromosome 7
D) Multilobular nucleus with enzyme filled granules
E) Menopause due to decreased in inhibin
F) Short stature and ovarian dysgenesis
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  #2  
Old 05-23-2012
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C- cystic fibrosis , decreased female fertility males are sterile with absence of vas
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  #3  
Old 05-23-2012
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Hm... Well I guess CF fits in here...

But what laboratory study shows everything within normal limits ???
not necesserily fair.

If it was a lab test for sweat chloride or something - it would be abnormal, right?

So Answer B could be fine too (if she was tested for sweat chloride and it was fine) Like she would have Kartagener and "LAB" would not do a ct or auscultation to find a heart on a right side or sompin.

URI do ring a bell for CF.
answer - C
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Old 05-23-2012
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Quote:
Originally Posted by DocSikorski View Post
Hm... Well I guess CF fits in here...

But what laboratory study shows everything within normal limits ???
not necesserily fair.

If it was a lab test for sweat chloride or something - it would be abnormal, right?

So Answer B could be fine too (if she was tested for sweat chloride and it was fine) Like she would have Kartagener and "LAB" would not do a ct or auscultation to find a heart on a right side or sompin.

URI do ring a bell for CF.
answer - C

Finally what's your answer?
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Old 05-23-2012
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Quote:
Originally Posted by alfjof View Post
Finally what's your answer?
meh, Ill probably overthink myself in here, but I will say its Kartagener versus CF. Even though there is a form of CF with normal sweat Cl level...

Final answer - B
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Old 05-23-2012
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I'd go with Kartegeners here. Cystic fibrosis presenting as just an URI and infertility at a late 28 years? Unlikely presentation in an exam.
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Old 05-23-2012
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Its B....Kartagener syn.....

but that raises a doubt-- whats the mechanism of female sterility in kartagener syn????

in females, ciliated epithelium is seen in fallopian tubes which assist the migration of zygote towards the uterus..is the tubal motility or the ciliary action predominant in moving the zygote?????? i feel its the muscular action of tubes that have an upper hand????
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I'll have to go with B too, even though I remember reading cilia are not really necessary for the movement of the ova along the fallopian tube to the uterus. Apparently peristaltic movement of the tube is what's really much more important for moment of the ova down to the uterus.

But since lab tests are within normal, that eliminates CF.
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Old 05-23-2012
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Answer is B
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Old 05-24-2012
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wow , that is the kind of questions I like most

off course B , Kartagner
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Old 05-24-2012
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B is the correct answer
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