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Old 05-31-2012
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Liver Cholestasis without jaundice?

Cholestasis may occur without jaundice because of the capacity of the liver to continue to secrete bile sufficiently until the injury to the bile ducts is significant.
can any 1 explain?
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Old 05-31-2012
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In cholestasis, the mechanism for bilirubin to appear in the blood is by extravasation(if you can call it that) from the bile ducts. So liver keeps secreting bile but you'll only see jaiundice when it leaks from the ducts.

And we're not talking about bilirubin secretion defects like rotor or dubin-johnson here. In these two, the conjugated bilirubin goes out of the liver cells directly into the blood stream, through the same channels through which it comes in.
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Gastrointestinal-Tract-, Physiology-

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