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  #1  
Old 05-31-2012
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Biochemistry Alcohol Toxicity Which Enzyme?

A sexually 19-year-old girl has been detected with gardnerella vaginalis 4 days ago, go to a party and enjoy a couple cup of soda, food, and wine. 30 minutes after the girl begins flushing, vomiting, headache accompanied by tachycardia, vertigo, nausea, and anxiety. Below is a diagram depicting alcohol metabolism. Elevated levels of which of the following substance in the diagram may lead to the adverse effect described above?

Alcohol Toxicity Which Enzyme?-.png
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A)
B)
C)
D)
E)



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Old 05-31-2012
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C

Due to accumulation of acetaldehyde.. She must be on Metronidazole which has Disulfiram like reaction by inhibiting Aldehyde dehydrogenase which converts acetaldehyde into non toxic Acetate .. So, those taking Metronidazole should avoid alcohol
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Old 05-31-2012
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I think c , not sure
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Quote:
Originally Posted by Rookie View Post
C

Due to accumulation of acetaldehyde.. She must be on Metronidazole which has Disulfiram like reaction by inhibiting Aldehyde dehydrogenase which converts acetaldehyde into non toxic Acetate .. So, those taking Metronidazole should avoid alcohol
Nice.. I agree.
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Metronidazole clinical use -treats gardnerella vaginalis.
Toxicity-disulfiram-like reaction with alcohol
disulfiram-inhibits accetaldehyde dehydrogenase,acetaldehyde accumulates ,contributing to hangover symptoms
ENZYME 1-ALCOHOL DEHYDROGENASE
ENZYME 2-ACETALDEHYDE DEHYDROGENAZE
A-NAD+
B-NADH
C-ACETALDEHYDE
D-NAD+
NADH
answer is c
fa 2012 -100,211

Last edited by irakly; 05-31-2012 at 08:46 PM.
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Old 05-31-2012
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disulfiram-like effect secondary to TMP-SMX??? I think is C

Man... I like your Qs... thank you very much...
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Old 06-01-2012
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Originally Posted by Dr. Mexito View Post
disulfiram-like effect secondary to TMP-SMX??? I think is C

Man... I like your Qs... thank you very much...

You are welcome!!!!!! I believe you don't need the answer because irakly and rookie gave us all detail we need
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