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Old 06-01-2012
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Drug Beta Agonist effect on Potassium Level

I have a question -

How do beta agonist lead to hypokalemia. I know they shift K+ into the cell and cause hypokalemia but why ? Also what's an overall effect on the metabolic panel due to beta agonists. This is my reasoning and please tell me if its right -

1) Increased sympathetic tone = Increased Renin = Increased Angiotensin II (vasoconstricts efferent arterioles = Increased GFR & Filtered fraction) = Increased Aldosterone = Increased Na+ & H2O retention and Increased K+ secretion (HYPOkalemia)

2) Beta Agonist = Increased Insulin secretion = Increased K+ shift into cells = HYPOkalemia


Is that correct ?
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Old 06-01-2012
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I think these are the correct mechanism on how beta agonists affect the potassium levels...

beta 1 receptors increase in renin release and beta 2 receptors cause increase in insulin release...
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Old 06-02-2012
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yep, that is correct.
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Old 06-02-2012
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isn't it beta 1 for insulin too ??
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Quote:
Originally Posted by ..sharma View Post
isn't it beta 1 for insulin too ??
Remember it this way -
Alpha = always decreases
Beta = always increases


RenIn has 1 I therefore ALPHA 1 Decreases renin and BETA 1 increases Renin.

InsulIn has 2 I's therefore ALPHA 2 Decreases Insulin and BETA 2 Increases Insulin.
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neat ...
thanks...
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Old 06-02-2012
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Quote:
Originally Posted by Hope2Pass View Post
Remember it this way -
Alpha = always decreases
Beta = always increases


RenIn has 1 I therefore ALPHA 1 Decreases renin and BETA 1 increases Renin.

InsulIn has 2 I's therefore ALPHA 2 Decreases Insulin and BETA 2 Increases Insulin.
Wow, thats a handy little mnemonic right there! Thanks!
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