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Old 06-03-2012
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Liver liver disease and macrocytic anemia

can anyone explain how liver disease can cause NONmegalocytic anaemia ??
I previously read it but I dont remember where and I forgot all about it
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Old 06-03-2012
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in liver disease...decreased synthesis of liver plasma proteins ------>dcreased serum level of clotting factors,,,,,,,,,,,,,factor 2,7.9 10 are synthesised in hepatocytes ...thus their production decreased. in liver disease----->prolongation of PT Hemorrhage may occur as a complication of chronic liver disease because of a lack of one or more liver-produced blood clotting factors,other causes include,portal hypertension associated varices, thus iron deficiency anaemia can occur.....hope it works
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Old 08-26-2012
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Originally Posted by mam86 View Post
in liver disease...decreased synthesis of liver plasma proteins ------>dcreased serum level of clotting factors,,,,,,,,,,,,,factor 2,7.9 10 are synthesised in hepatocytes ...thus their production decreased. in liver disease----->prolongation of PT Hemorrhage may occur as a complication of chronic liver disease because of a lack of one or more liver-produced blood clotting factors,other causes include,portal hypertension associated varices, thus iron deficiency anaemia can occur.....hope it works
It's not iron deficiency. It's macrocyclic non megaloblastic anemia, and that's not iron deficiency result.
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Old 08-26-2012
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Alcohol causes macrocytic anemia without RBC's DNA impairment, as well as liver diseases, I know the reason behind that is reticulocytosis, the both increase retic count, but why, that what I don't know !!
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Old 08-26-2012
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i'm not 100% sure, but i remember from goljan....
that in liver disease (mcc is alcohol excess).....increase in RBC membrane due to increased membrane cholesterol lead to MCV > 100....
and also goljan says in non megaloblastic macrocytic anemias anemias may not be present(only macrocytosis present).
alcohol may cause anemia by decreasing the RBC precursors release from bone marrow..
abstinence from alcohol decreases macrocytosis and anemia...
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