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  #1  
Old 06-08-2012
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Question Ovary secrete Testosterone!

Does the ovary secrete testosterone?
I just cant understand the figure on FA 2011 p497, !!!

Can anyone help
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Yes
Some testosterone is formed but most are aromatized to estradiol
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The theca cells produce androgens (testosterone) that are coverted to estradiol by the granulosa cells via aromatase.
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Quote:
Originally Posted by slowpoke View Post
The theca cells produce androgens (testosterone) that are coverted to estradiol by the granulosa cells via aromatase.

yes but is there free testeterone in female body or it is all converted
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Quote:
Originally Posted by mycoplasma View Post
yes but is there free testeterone in female body or it is all converted
Yes there are testosterone\androgens in the female body, because their excess can cause virulization and hersutism,,, males also have estrogen and prolactin in their bodies, everything is everywhere in both sexes,

Its all just a matter of amounts and ratios and concentrations... Imbalences cause pathology.
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thanks alot all , but if u can help I have another questions
1-why estrogen used in androgen dependent prostatic Cancer ??
2 - why testesterone used for estrogen positive breast Cancer ??
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also need to make sure I understand this right ,
in androgrn insensitivity syndrome , there is testes , but no internal female or male genitalia , and there is external female genitalia
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Quote:
Originally Posted by mycoplasma View Post
thanks alot all , but if u can help I have another questions
1-why estrogen used in androgen dependent prostatic Cancer ??
2 - why testesterone used for estrogen positive breast Cancer ??
you said it.... androgen dependant prostate cancer, which mean too much androgen makes it grow.. if we could somehow supress the androgen,, the tumor wont grow as much..... androgen supression is by decreasing LH\FSH release from the pituitary....
LH\FSh release from the pituatry is under normal negativ efeedback by the products [estrogen\testosterone]... so if we give the patients the steroids, the LH\FSH secretion would stop

it's ok to give a male estrogen to supress his androgen dependant prostate cancer,, but it would be totally stupid to give a female estrogen cause it will just make her cancer worse, so we give her testosterone..... same thing for man but the opposite, we cant give him testostrone, so we administer estrogen




side effects result ofcourse depending on what the patient recieves [estrogen causes gynecomastia in men], androgens [cause hair growth and acne in women]

hope its clear like that
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Quote:
Originally Posted by mycoplasma View Post
also need to make sure I understand this right ,
in androgrn insensitivity syndrome , there is testes , but no internal female or male genitalia , and there is external female genitalia

androgen insensitivity... androgen is produced by the testes, but it's effects are absent coz all of the testosterone receptors in everyplace in the body are messed up and dont function, so yes like u said
-no internal female [because they are supressed by the antimullerian factor] which functions normally and doesnt depend on testosterone.

-no internal or external male [because they need testosterone and DHT to develope]

-external genitalia is female like, but small vagina and small labia majora[coz they normally need lots of estrogen to develop, which is found in a female, but this guy here is a male with XY..no estrogen available here],,, and the testes are found in the labia majora
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oh thank you so much that was much helpful
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Old 07-03-2012
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There are many problems exists regarding the problem of Testosterone. The problems may exists due to the values of LH/RH or some others. There are many online stores providing the drugs for these problems. These should be taken under proper specialist consultation. Produce some more attachments for the more detailed view.
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