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Old 06-12-2012
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Goljan I dont' understand the HLA haplotype matching

Could someone please explain the table:3.1 of Goljan rapid review of pathology based on HLA haplotype matching in immunopathlogy section???? I just don't get it..............don't know why???? might be from the stress of academic exam now going on.....
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Old 06-13-2012
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Default goljan table on hla matching

With the given father and mother haplotypes...4 types of haplotype combinations possible...just like in genetics...0 haplotype match means not matching with pt haplotype..1 haplotype match means only one of d two alleles is common with pt, 2 haplotype match means both the two alleles are matching with pt....here say pt haplotype is A2B2C2D2/A4B4C4D4...with the 4 possible combinations u can hav only one dat is 2 haplotype match with the pt...dat means 1 in 4 =25% chance of 2 haplotype match and
the haplotype of A1B1C1D1/A3B3C3D3 not at all matching so its 0 haplotype match and it is also 1 in 4=25% and there are two other haplotypes A1B1C1D1/A4B4C4D4 dis one is only 1 haplotype match coz only dis A4...... part is in common vit d pt...same way A2B2C2D2/A3B3C3D3 only d A2.......part is matching vit pt...so dis is also 1 haplotype match...thus there r 2 combinations that are 1 haplotype match...2 in 4=50%
Hope its clear now...
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Old 06-13-2012
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TRY THIS ONE
http://www.stanford.edu/dept/HPS/tra.../html/hla.html
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