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Old 06-14-2012
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Liver What's the etiology of this man's liver cancer?

A 51-year-old man who works in a factory that produces plastic pipe has experienced weight loss, nausea, and vomiting over the past 4 months. On physical examination, he has tenderness to palpation in the right upper quadrant of the abdomen, and the liver span is increased. Laboratory findings include serum alkaline phosphatase, 405 U/L; AST, 45 U/L; ALT, 30 U/L; and total bilirubin, 0.9 mg/dL. An abdominal CT scan shows a 12-cm mass in the right lobe of the liver. A liver biopsy is performed, and microscopic examination shows an angiosarcoma. The patient has most likely been exposed to which of the following agents?
(A) Arsenic
(B) Asbestos
(C) Benzene
(D) Beryllium
(E) Nickel
(F) Vinyl chloride
(G) Naphthalene
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Liver Angiosarcoma can be caused by Vinyl Chloride, Arsenic and Thorotrast.

Given the pts history of working in a factory producing plastic pipes, I'd go with F) Vinyl Chloride.
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Old 06-14-2012
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Yeah def go with F
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Quote:
Originally Posted by anomali View Post
A 51-year-old man who works in a factory that produces plastic pipe has experienced weight loss, nausea, and vomiting over the past 4 months. On physical examination, he has tenderness to palpation in the right upper quadrant of the abdomen, and the liver span is increased. Laboratory findings include serum alkaline phosphatase, 405 U/L; AST, 45 U/L; ALT, 30 U/L; and total bilirubin, 0.9 mg/dL. An abdominal CT scan shows a 12-cm mass in the right lobe of the liver. A liver biopsy is performed, and microscopic examination shows an angiosarcoma. The patient has most likely been exposed to which of the following agents?
(A) Arsenic
(B) Asbestos
(C) Benzene
(D) Beryllium
(E) Nickel
(F) Vinyl chloride
(G) Naphthalene
obviously the best option here is vinyl chloride for Liver Angiosarcoma
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Old 06-14-2012
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Yeah i would go with F aswell, the question is can someone explain why it's a better option then arsenic? if i would have seen the question i would have picked A before even looking on the other answers, thats a bad reflex i know...
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its vinyl chloride for sure... rmbr reading it in kaplan patho!!!! its F
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Quote:
Originally Posted by modesty View Post
Yeah i would go with F aswell, the question is can someone explain why it's a better option then arsenic? if i would have seen the question i would have picked A before even looking on the other answers, thats a bad reflex i know...
the key to answer is PLASTIC PIPE (PVC pipes and bottles).....

the right answer is indeed F......
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