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Old 06-14-2012
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Question woman with CA breast.

A 50-year-old woman saw her physician after noticing a mass in the right breast. Physical examination showed a 2-cm mass fixed to the underlying tissues beneath the areola and three firm, nontender, lymph nodes palpable in the right axilla. There was no family history of cancer. An excisional breast biopsy was performed, and microscopic examination showed a well-differentiated ductal carcinoma. Over the next 6 months, additional lymph nodes became enlarged, and CT scans showed nodules in the lung, liver, and brain. The patient died 9 months after diagnosis. Which of the following molecular abnormalities is most likely to be found in this setting?
(A) Inactivation of one BRCA1 gene copy
(B) Deletion of one p53 gene copy
(C) Amplification of the ERBB2 (HER2) gene
(D) Deletion of an RB gene locus
(E) Fusion of BCR and C-ABL genes
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Old 06-14-2012
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(C) Amplification of the ERBB2 (HER2) gene ....... ?
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Old 06-14-2012
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C..........
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Old 06-14-2012
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Hi,

Invasive ductal carcinomas are mostly associated with ERB2 amplification - and thats why they are also treated with trastuzumab. hence the answer C.
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Old 06-15-2012
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C is the correct answer....
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