How to confirm malignancy? - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 06-15-2012
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 791
Threads: 76
Thanked 673 Times in 317 Posts
Reputation: 691
Question How to confirm malignancy?

During a routine health maintenance examination, a 46-year-old man is found to have an enlarged, nontender supraclavicular lymph node that is palpable on physical examination. The 2-cm node is excised. Histologically, the nodal architecture is effaced by a monomorphous population of small lymphocytes. Which of the following procedures would best confirm that the patient has a malignancy?
(A) Peripheral WBC count and differential cell count
(B) Flow cytometry of nodal tissue for DNA content
(C) Electron microscopy to determine cellular ultrastructure
(D) Southern blot analysis to show monoclonality
(E) Determination of the serum lactate dehydrogenase level
Reply With Quote Quick reply to this message
The above post was thanked by:
curiousmind (06-25-2012), DefeatTheBeast (06-15-2012), Farrukh Munir (06-16-2012)



  #2  
Old 06-15-2012
USMLE Forums Guru
 
Steps History: Step 1 Only
Posts: 452
Threads: 11
Thanked 354 Times in 197 Posts
Reputation: 364
Default

D..........malignant cells show monoclonity
Reply With Quote Quick reply to this message
  #3  
Old 06-15-2012
Hope2Pass's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 1,684
Threads: 213
Thanked 1,597 Times in 660 Posts
Reputation: 1607
Default

Quote:
Originally Posted by DefeatTheBeast View Post
D..........malignant cells show monoclonity
Not necessarily. If a tumor is not uniform, undifferentiated and of unknown origin then its said to be Polyclonal. BUT the theory is that all cancer cells originate from one precursor cell and therefore monoclonal is the more widely accepted theory unless prove otherwise (which is very hard lol).

But for the USMLE, you're right, malignant cells show monoclonality. So I'd go with D as well.
Reply With Quote Quick reply to this message
 
  #4  
Old 06-15-2012
USMLE Forums Master
 
Steps History: 1+CK+CS
Posts: 1,039
Threads: 189
Thanked 561 Times in 319 Posts
Reputation: 571
Default my answer :)

I think it's D

(A) Peripheral WBC count and differential cell count -> it's useful but it's not a definite source for establishing diagnosis of malignancy (we perform bone marrow or node biopsy)
(B) Flow cytometry of nodal tissue for DNA content -> DNA won't tell us whether it's B or T. if they said here 'flow cytometry for CD marker(s)' I would consider this as a possible answer
(C) Electron microscopy to determine cellular ultrastructure -> I haven't heard about cellular structure in leukemia that would allow us to say definitely that it's a malignancy
(D) Southern blot analysis to show monoclonality -that's my choice
(E) Determination of the serum lactate dehydrogenase level - this one I don't know what reason to give to exclude but I'm just not aware of any connection btw this answer and malignancy diagnosis
Reply With Quote Quick reply to this message
  #5  
Old 06-15-2012
USMLE Forums Addict
 
Steps History: 1 + CS
Posts: 160
Threads: 6
Thanked 47 Times in 38 Posts
Reputation: 57
Default

i would go with
D...
__________________
I am not 'THE BEST', but I am not like 'THE REST'..
Reply With Quote Quick reply to this message
  #6  
Old 06-16-2012
USMLE Forums Scout
 
Steps History: Step 1 Only
Posts: 27
Threads: 2
Thanked 11 Times in 5 Posts
Reputation: 21
Default

D ?
monoclonal ...tumor
polyclonal. ....hyperplasia
Reply With Quote Quick reply to this message
  #7  
Old 06-16-2012
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 791
Threads: 76
Thanked 673 Times in 317 Posts
Reputation: 691
Default

The answer is D.....as explained by H2P....
Reply With Quote Quick reply to this message



Reply

Tags
Pathology-, Step-1-Questions

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
Colon Polyps and Risk of Malignancy Evergreen USMLE Step 1 Forum 2 01-14-2012 06:04 PM
Malignancy for MIBG scan scopusmount USMLE Step 1 Forum 9 11-07-2011 08:24 AM
Diabetic Skin Lesion and Malignancy Risk! ricko335 USMLE Step 1 Forum 31 09-10-2011 04:32 PM
congenital defect leading to malignancy ricko335 USMLE Step 1 Forum 7 08-16-2011 08:46 AM
What is the similarity between Hyperclcemia of malignancy and Diabetes insupidus? struggle USMLE Step 1 Forum 2 05-27-2011 12:07 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)