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Old 06-15-2012
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Question Tumor Cells and Response to Treatment!

A 60-year-old man comes to his physician because he has noted a mass in his neck that has increased rapidly in size over the past 2 months. On physical examination, a firm, nontender, 10-cm mass in the left lateral posterior neck that appears to be fused to cervical lymph nodes is palpated. Hepatosplenomegaly is noted. A head CT scan reveals a mass in the Waldeyer ring near the pharynx. A biopsy of the neck mass is performed, and on microscopic examination the biopsy specimen shows abnormal lymphoid cells with many mitotic figures and many apoptotic nuclei. The patient is treated with a cocktail of cell cycle–acting chemotherapeutic agents. The cervical and oral masses shrink dramatically over the next month. Based on his history and response to treatment, the tumor cells are most likely to have which of the following features?
(A) Limited capacity to metastasize
(B) Polyclonality
(C) Poor vascularity
(D) High growth fraction
(E) Strong expression of tumor antigens
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  #2  
Old 06-15-2012
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Default my answer :)

I think it's (D) High growth fraction

If using cell-cycle-acting chemo worked it means the cells are dividing rapidly.
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Old 06-15-2012
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High growth frąction,
Its D)...
And if its Burkitt's , then its due to c-myc oncogenes in chromosome 8..that makes cells dividing crazy...and dramatically response to chemo....

Axxxx....hope m right...
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Old 06-16-2012
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D is the correct option
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