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Old 06-19-2012
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Default NBME 1 question - digeorge syndrome

I have a question from NBME 1. Level of gamma globulins will be normal or deceased in DiGeorge syndrome?

As far as i know most of the antibodies are IgG, and they will not be synthesized in absence of T-cells.
So what should be gamma globulin level??
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Old 06-19-2012
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I thought only B-cell disorders (whether pure or mixed with t-cell disorders) have aggamaglobulinemia (or hypogammaglobulinemia).

I never thought pure t-cell disorders could cause decreased gammaglobulinemia.
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Old 06-19-2012
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what a sick question from those NBMEs
internet says that they will have normal levels of Ig, unless its very severe.. their Ig levels will decrease

my exam is in 5 days and never came across such an idea for a question neither read about it in a book or uni :\\
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Old 06-19-2012
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Quote:
Originally Posted by drhma View Post
what a sick question from those NBMEs
internet says that they will have normal levels of Ig, unless its very severe.. their Ig levels will decrease

my exam is in 5 days and never came across such an idea for a question neither read about it in a book or uni :\\
YOu have normal b cells, but remember, you need T cells (costimulatory signal) for class switch to occur. So, answer must be low gammaglobulin levels but normal B cells and low/none T cells (Depending on the level of immunosuppression). You still have complement and IgM ---> antibacterial defense
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