Peutz-Jeghers Syndrome and risk of Colon Cancer! - USMLE Forums
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  #1  
Old 06-24-2012
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GIT Peutz-Jeghers Syndrome and risk of Colon Cancer!

Hey guys,
In first aid Peutz-Jeghers syndrome (all of us know it hamartomatas polyps) lead to clono cancer but goljan in his audio said that never peutz jegher cause colon cancer i am confused what is the best answer
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  #2  
Old 06-24-2012
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Hi, PJ syndrome is associated with some visceral malignancy (pancreatic, etc.) but not colon cancer!
The information in first aid has been fixed with the newest errata.
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Old 06-24-2012
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heyy thank you by the way its not in 2011 errata it is in 2012?
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Old 06-24-2012
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Hmmm....in pathoma it also states its associated with colorectal and i didn't find anything in the 2011 errata
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Old 06-24-2012
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Im sorry, it's not found in the errata i have deleted it from the book by myself i guess as i have a cross over it.
I guess i have also brought it from Goljan, i have just checked in Robbins the full edition and it states that it does increase the risk for colon cancer, in this case i will go with Robbins.
Sorry for misleading.
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Old 06-24-2012
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Quote:
Originally Posted by modesty View Post
Im sorry, it's not found in the errata i have deleted it from the book by myself i guess as i have a cross over it.
I guess i have also brought it from Goljan, i have just checked in Robbins the full edition and it states that it does increase the risk for colon cancer, in this case i will go with Robbins.
Sorry for misleading.
No worries dude better we fix our mistakes now then the exam!
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Old 06-24-2012
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thannnnk you veryy much
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Old 06-24-2012
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Yes it inceases the risk of GI and genital system cancer . But Colorectal cancer isn't derived from this hamartomous polyps, these are 2 distinctive processes happening independent from each other.
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Old 06-24-2012
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Peutz jeghers is associated with increased risk of colonic malignancy. Whether the cancer arises from the hamartomatous polyp or denovo from the mucosa is still under debate, I think.

http://www.ncbi.nlm.nih.gov/pmc/arti...tool=pmcentrez
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Old 06-24-2012
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Previously discussed here
Peutz-Jeghers and risk of malignant transformation

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Gastrointestinal-Tract-, Pathology-, Syndromes-Acronyms

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