Insulin resistance - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 06-24-2012
USMLE Forums Master
 
Steps History: 1 + CS
Posts: 675
Threads: 84
Thanked 426 Times in 206 Posts
Reputation: 436
Default Insulin resistance

Why does phosphorylation of threonine and serine residues lead to insulin resistance?
Does it have to do with the signalling pathway insulin uses (tyrosine kinase -MAP kinase pathway)?
Reply With Quote Quick reply to this message



  #2  
Old 06-24-2012
USMLE Forums Addict
 
Steps History: 1+CK+CS
Posts: 194
Threads: 21
Thanked 145 Times in 84 Posts
Reputation: 155
Default

I have seen a similar question in UW.

Serine/threonine kinases phosphorylate IRS1 in different locations then the tyrosine kinase which is activated by insulin, practically rendering IRS inactive as it cant be phosphorylated by the tyrosine kinase afterward.
So that's how they "Degrade" the insulin pathway as IRS cant work.

I think the question was about how TNFalpha induces insulin resistance - anyhow in UW it seemed like a picky low yield question.
Reply With Quote Quick reply to this message
  #3  
Old 06-24-2012
USMLE Forums Master
 
Steps History: 1 + CS
Posts: 675
Threads: 84
Thanked 426 Times in 206 Posts
Reputation: 436
Default

Seems pretty low yield yeah, but im asking so i can draw the big picture in my head. Because there's a question in NBME 5 i just remembered, asking about the signalling pathway of some growth factor (the same pathway of insulin), and i always get mixed up with the phosphorylation and dephosphorylation of this stuff!

Thnx!
Reply With Quote Quick reply to this message



Reply

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
Potassium Insulin Relationship Ahmed-USMLE USMLE Step 1 Bits & Pieces 14 08-08-2016 12:27 PM
Child wants to inject insulin himself! riya10 USMLE Step 1 Forum 1 03-22-2012 09:17 PM
Exogenous vs Endogenous insulin jahn77 USMLE Step 1 Forum 7 07-07-2011 07:16 AM
Insulin receptor jahn77 USMLE Step 1 Forum 0 07-03-2011 09:07 PM
The concept of Insulin Resistance jattdoc USMLE Step 1 Forum 2 06-29-2011 04:35 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)