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Old 06-25-2012
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Default what is role of stress hormone on proteins... doubt regarding cushing and acromegaly...please help.

what is role of stress hormone on proteins... doubt regarding cushing and acromegaly...please help.

i read that in cushing [ cortisol excess = stress hormone ] there is gluconeogenesis and muscle wasting.

in acromegaly, [ growth hormone excess = stress hormone ] there is muscle build up.

so what exactly is role of stress hormones ?
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Originally Posted by tyagee View Post
what is role of stress hormone on proteins... doubt regarding cushing and acromegaly...please help.

i read that in cushing [ cortisol excess = stress hormone ] there is gluconeogenesis and muscle wasting.

in acromegaly, [ growth hormone excess = stress hormone ] there is muscle build up.

so what exactly is role of stress hormones ?
Stress Hormone is a broad term for: 1)Epinephrine, 2)Cortisol, 3)Growth Hormone and 4)Glucagon. So firstly, we can't say that they will ALL function exactly the same. What they have in common is how they work in conditions of stress, where they primarily increase the concentration of glucose in the blood.

Now, Growth Hormone is both a stress hormone and an anabolic hormone. So remember that the two roles are different. It is a stress hormone because in states of stress (exercise, hypoglycemia etc.), it tends to increase glucose in the blood. It also increases lipolysis. Now, it's anabolic effect is different from it's stress hormone role. As an anabloic hormone, it increases lean muscle mass by increasing amino acid uptake by muscle. So where protein is concerned, it doesn't act as a stress hormone. Also remember that it's anabolic effect is mostly indirect via IGF and it's stress hormone role is direct.

As for cortisol, this hormone breaks down all three ie: Proteins, Glycogen and Triglycerides. The net effect is to increase glycogenolysis, as well as gluconeogenesis by using the amino acids and fatty acids released to provide the carbon skeleton and ATP. Net affect: Plasma glucose levels rise for tissues to use, just like the stress hormone effect of Growth Hormone. Hope that helped!

I want to add two more things. One, that Epinephrine is the only stress hormone that has NO effect of any kind on Proteins. And two, my mnemonic for stress hormones is 'ECGG'. You get an ECG done is a stressful situation for a heart patient.
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