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Old 06-25-2012
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Default cholestyramine and triglyceride levels

Cholestyramine has a tendency to raise triglyceride levels, especially in patients with baseline hypertriglyceridemia

can any1 please tell the reason for the same. regarding mechanism of action, it is bile sequesterant and works at level of gut. then how come it raises TG levels ?
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Old 06-25-2012
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It's true the bile binding resins can elevate TG, although it doesnt always happen!
But about your question, i think it's associated with the fact that the liver will synthesize more VLDL in response to the Cholesterol and TG deprivation as they are not absorbed through the GI, more VLDL -> hyper TG.
The other drugs like Niacin and even statins have the ability also to block the synthesis of VLDL so thats why you dont suffer from the rebound hyper TG by the liver.
Fibrates of course are directed against TG by activating LPL so although the liver will increase the VLDL formation it will be sequestrated in the tissues by LPL activity.
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