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  #1  
Old 06-26-2012
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Default It's 1 am and a hard working medical student...

It's 1 am and a hard working medical student/graduate is intent on finishing her pathology reading for Step 1 exam. Soon she begins to note that her concentration is fading, because 7 hours have passed since she had dinner, and she is feeling famished. Having studied the chapter on ischemic heart disease, she decides to be prudent and forgoes her favorite chocolate cookies, and instead devours 2 apples, gulping them down with a glass of low fat milk. Of the following substances, which one was most likely to have risen rapidly when she became hungry and declined promptly after she finished her healthy snack?

a) ghrelin
b) leptin
c) corticotropin releasing factor (CRF)
d) alpha-MSH
e) thyrotropin releasing hormone (TRH)

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Old 06-26-2012
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Correct Answer

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Originally Posted by Casandra View Post
It's 1 am and a hard working medical student/graduate is intent on finishing her pathology reading for Step 1 exam. Soon she begins to note that her concentration is fading, because 7 hours have passed since she had dinner, and she is feeling famished. Having studied the chapter on ischemic heart disease, she decides to be prudent and forgoes her favorite chocolate cookies, and instead devours 2 apples, gulping them down with a glass of low fat milk. Of the following substances, which one was most likely to have risen rapidly when she became hungry and declined promptly after she finished her healthy snack?

a) ghrelin
b) leptin
c) corticotropin releasing factor (CRF)
d) alpha-MSH
e) thyrotropin releasing hormone (TRH)



Nice question from robbins
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  #3  
Old 06-26-2012
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corticotropin releasing hormone

cortisol is a strees hormone , usually rises early hours in the morning i.e 2-3 am , but also depends on the last meal .

hence CRH releases ACTH releasing cortisol .

cortisol promotes glycogenolysis and gluconeogenesis .
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Old 06-26-2012
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Hi
I think the answer is A) Ghrelin by exclusion of the other items..
BTW I found this on wikipedia about ghrelin:
Ghrelin is a 28 amino acid hunger-stimulating peptide and hormone that is produced mainly by P/D1 cells lining the fundus of the human stomach and epsilon cells of the pancreas.[1] Ghrelin levels increase before meals and decrease after meals. It is considered the counterpart of the hormone leptin, produced by adipose tissue, which induces satiation when present at higher levels. In some bariatric procedures, the level of ghrelin is reduced in patients, thus causing satiation before it would normally occur
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Old 06-26-2012
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its Ghrelin,talk about hunger and pre and post prandial in this question its ghrelin and by the ways the stress hormones are released when really under stress.psychological stress like exams etc., doesn't play a dominant role in releasing the stress hormones.severe physical stress/post op stress/injury stress factors like these causes stress hormone release.
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Old 06-26-2012
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I think its A... b/c ghrelin is the hormones that induces hunger... and decreases after a meal!!!
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Old 06-26-2012
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Ghrelin..


She had her dinner at 6pm !! That would be my snack time lol... Excuse me for going off from the topic.. But I couldnt stop myself from wondering how could she go so long without munching around in between.. Then I realize Dedication you see..
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Old 06-28-2012
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Default correct answer

Correct answer is A) ghrelin

The levels of ghrelin produced in the stomach rise rapidly before every meal and fall promptly after the stomach is filled. This is a short-term acting appetite and satiety controll complex.

@j-sin - and idea with CRF is good regarding the time, but CRF wouldn't have declined rapidly after the meal.
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Old 06-28-2012
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Thanks for this question....i was unaware of ghrelin untill now...
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