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Old 06-26-2012
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Default A 17-year-old girl has hundreds of skin lesions

A 17-year-old girl has hundreds of skin lesions on her body that have been forming since childhood. On physical examination, 0.4- to 1.7-cm, macular to slightly raised, plaquelike, dark brown pigmented lesions are present on sunexposed and non–sun-exposed areas of skin. The lesions have irregular contours, and there is variability in pigmentation. She says that her 15-year-old brother has similar lesions. Which of the following molecular changes are most likely to be present in the DNA from this patient?
(A) Deletion of the von Hippel–Lindau (VHL) gene
(B) Mutation of the PTCH gene
(C) Integration of the human papillomavirus-16 (HPV-16) genome
(D) Deletion of the p16/INK4A (CDNK2) gene
(E) Microsatellite instability
(F) Ultraviolet light–induced damage from pyrimidine dimmers
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Old 06-26-2012
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Hi
I think D is the answer. Deletion of p16 is associated with melanoma development.
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Old 06-26-2012
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Default Explanation!

The answer is D: Tumor suppressor gene p16, deletion in 9p= Melanoma the dx is making by S100+HMB45+Melan A. this question from USMLERX
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