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Old 06-27-2012
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Default 4 year old boy with elevated WBC count.

A 4 year old boy is referred to a specialist for the diagnosis of a possible immunological problem. the child has extremely elevated WBC counts with a profound lymphocytosis. a biopsy performed on cervical LN reveals hypocellularity in both cortical and para cortical areas. Absence of which fo the following leukocyte surface markers would result in this clinical picture:

1.addressins
2.Chemokines
3.Ig family cell adhesion Molecules
4. intergins
5. L-selectins.
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Old 06-27-2012
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Quote:
Originally Posted by sleepy View Post
A 4 year old boy is referred to a specialist for the diagnosis of a possible immunological problem. the child has extremely elevated WBC counts with a profound lymphocytosis. a biopsy performed on cervical LN reveals hypocellularity in both cortical and para cortical areas. Absence of which fo the following leukocyte surface markers would result in this clinical picture:

1.addressins
2.Chemokines
3.Ig family cell adhesion Molecules
4. intergins
5. L-selectins.

4..intergrins(CD !8)
Leukocyte adhesion def
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Old 06-27-2012
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answer is A...ADDRESSINS.....absence of these adhesion molecules lead to problems related to "HOMING" of lymphocytes to lymph nodes and hence elevated levels of B and T cells in peripheral circulation......
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