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Old 06-25-2010
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Microscope Scaly Patch on the Nipple!

A 38-year-old nulliparous woman comes to the physician for an annual check-up. She reports a 10-pack-year smoking history and a family history of early mastectomy. Physical examination is notable for a scaly patch on her right nipple. On palpation, there is a firm mass and a clear discharge from the nipple. Which of the following would most likely be seen on a histological examination of this mass?
(A) Intralobular clusters of tumor cells
(B) Large cells with clear halos
(C) Lymphocytic infi ltration
(D) Necrosis
(E) Pools of mucus
(F) Proliferation of normal epithelial cells
(G) Proliferation of normal glands and ducts
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Old 06-25-2010
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Choice B.
Large, epithelial cells with clear cytoplasm associated with Paget's disease
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Old 06-25-2010
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(B) Large cells with clear halos...paget's cells
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Old 06-27-2010
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yes ans is paget dx. large cells in epidermis with clear halos
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