Dubin Johnson and Coproporphyrins level! - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
USMLE Articles
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam

Thread Tools Search this Thread Display Modes
Old 06-30-2012
tyagee's Avatar
USMLE Forums Master
Steps History: ---
Posts: 1,365
Threads: 648
Thanked 584 Times in 354 Posts
Reputation: 594
Liver Dubin Johnson and Coproporphyrins level!

Please can any you please explain this
Dubin·Johnson syndrome distinguished from rotor syndrome by its lack of elevation of coproporphyrins
Reply With Quote Quick reply to this message

Old 07-07-2012
USMLE Forums Addict
Steps History: 1+CK+CS
Posts: 196
Threads: 9
Thanked 96 Times in 64 Posts
Reputation: 106

The defect in Dubin-johnson syndrome is a mutation that decreases activity of the MDR2 transporting protein, which pumps out anions from cells. Coproporphyrin and bilirubin are both excreted by the same channel, thats why copro levels are high.

The MDR2 gene is similar to the MDR1 gene that was tested in one of the pharma UW questions. Its been found that some drug resistant tumor cells show increased expression of these proteins on their cell surface.
Reply With Quote Quick reply to this message
Old 09-12-2013
USMLE Forums Scout
Steps History: Not yet
Posts: 21
Threads: 0
Thanked 12 Times in 8 Posts
Reputation: 22

Originally Posted by tyagee View Post
Please can any you please explain this
  • in rotor syndrome like many aquired liver disorders corpoporphyrin I cant be secreted in Bile, and its secreted in Urine so the Total Urine Corpoporphyrin rises in rotor syndrome. however in Dubin johnson syndrome although urine corpoporphyrin I is high the Total corpoporphyrin remains normal.
Reply With Quote Quick reply to this message


Gastrointestinal-Tract-, Pathology-

Quick Reply

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Please enter a password for your user account. Note that passwords are case-sensitive.
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Where you live. Leave blank if you don't want to tell.


Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.

Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes

Similar Threads
Thread Thread Starter Forum Replies Last Post
What LDL level? usmledee USMLE Step 2 CK Forum 1 02-27-2012 03:39 AM
Ellinghausen-McCullough-Johnson-Harris Growth Medium Evergreen USMLE Step 1 Forum 5 01-16-2012 08:06 PM
Looking for USMLE Step 2 CS study partner in Johnson city / Tennessee MhdSafadi USMLE Step 2 CS Study Partners 0 06-19-2011 11:51 AM
DKA and Potassium Level hippocampus USMLE Step 1 Forum 13 07-16-2010 08:27 AM
Differentiating Staphylococcal Scalded Skin Syndrome from Toxic Epidermal Necrolysis and Steven Johnson Syndrome lee-usmle USMLE Step 2 CK Bits & Pieces 0 03-21-2010 06:12 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2016 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)