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Old 06-30-2012
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Liver Dubin Johnson and Coproporphyrins level!

Please can any you please explain this
Dubin·Johnson syndrome distinguished from rotor syndrome by its lack of elevation of coproporphyrins
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Old 07-07-2012
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The defect in Dubin-johnson syndrome is a mutation that decreases activity of the MDR2 transporting protein, which pumps out anions from cells. Coproporphyrin and bilirubin are both excreted by the same channel, thats why copro levels are high.

The MDR2 gene is similar to the MDR1 gene that was tested in one of the pharma UW questions. Its been found that some drug resistant tumor cells show increased expression of these proteins on their cell surface.
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Old 09-12-2013
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Originally Posted by tyagee View Post
Please can any you please explain this
  • in rotor syndrome like many aquired liver disorders corpoporphyrin I cant be secreted in Bile, and its secreted in Urine so the Total Urine Corpoporphyrin rises in rotor syndrome. however in Dubin johnson syndrome although urine corpoporphyrin I is high the Total corpoporphyrin remains normal.
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Gastrointestinal-Tract-, Pathology-

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