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Old 06-30-2012
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GIT Esophageal Basal Squamous Epithelial Hyperplasia

A 57-year-ol woman has had burning epigastric pain after meals for more than 1 year. Physical examination shows no abnormal findings. Upper GI endoscopy shows an erythematous patch in the lower esophageal mucosa. A biopsy specimen shows basal squamous epithelial hyperplasia, elongation of lamina propia papillae, and scattered intraepithelial neutrophils with some eosinophils. Which of the following is the most likely diagnosis?

a) Barret esophagus
b) Esophageal varices
c) Reflux esophagitis
d) Scleroderma
e) Iron deficiency

Please try to briefly explain your answer
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Old 06-30-2012
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I think the answer is C
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Old 06-30-2012
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Aaaa

metaplasia of esophageal stratified squamous epith to columnar nonciliated epithelium
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  #4  
Old 06-30-2012
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A)....
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Old 06-30-2012
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Guys you should be careful when you read the question.
There's nothing mentioned about metaplasia here and so it's not Barret.

This is a simple case of reflux esophagitis,
Here's a typical pathology description:

Quote:
Lesions distributed over the distal 8 cm of esophagus in a patchy fashion.
Histologic features include: hyperplasia of the esophageal squamous epithelium (basal cell hyperplasia > 15-20% of the total thickness of epithelium, subepithelial papillae of the lamina propria elongated >67-70% of the epithelium thickness), dilated blood vessels within lamina propria papillae, intraepithelial eosinophils, neutrophils and lymphocytes, erosions and ulcerations, thick parakeratosis. Most helpful features: epithelial hyperplasia and intraepithelial eosinophils (>6 per biopsy; lower numbers may be seen within squamous epithelium of the distal 1-2 cm where the physiologic reflux takes place).
Ref: http://www.gi-pathology.net/php/tuto...ment=esophagus
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Old 06-30-2012
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reflux esophagitis.....
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