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Old 06-30-2012
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GIT Colon Gross Pathology Image Question

A 43-year-old woman has become increasingly tired and listless over the past 5 months. She has had no menometrorrhagia for the past 3 months. On physical examination, there are no remarkable findings except for a positive result on stool guaiac testing. Laboratory studies show hemoglobin of 9.2 g/dl, hematocrit 27.3% and MCV 75 microm3. Pelvic ultrasound reveals an enlarged uterus. A Pap smear shows abnormal cells of probable endometrial origin. Colonoscopy is performed, followed by partial colectomy, with the gross appearance of the lesion shown in the figure. Which of the following molecular abnormalities has most likely led to these findings?

Colon Gross Pathology Image Question-question2.jpg
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a) Mutation in a DNA mismatch repair gene
b) Germ-line inheritance of an APC gene mutation
c) Tyrosine kinase activation due to c-KIT mutation
d) Homozygous loss of the PTEN gene
e) Inactivation of the Rb protein by HPV-16
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Old 06-30-2012
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A...(no polyps?)lynch syndrome
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Old 06-30-2012
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A)...??
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Old 06-30-2012
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Its lynch(HNPCC). ^ risk of colon cancer from non-polypoid dysplasia and endometrial hyperplasia/cancer and ovarian malignancy.
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A.....lynch syndrome
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Matched!!!
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Old 07-02-2012
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FA pg323!!

APC : thousands of polyps + pancolonic + always involves rectum
Mismatch repair (lynch syndrome): proximal colon always involved!!!
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Old 07-02-2012
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Hnpcc ,lynch syndrome-increased risk for colorectal cancer without previous polyps,inactivation of DNA mismatch repair genes(msh2,mlh1),cannot correct errors in nucleotide pairing,finding is alteration in microsatellite nucleotide sequences
goljan rr 129,352p-s
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