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Old 07-02-2012
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Question Confused on androgen Insensitive Syndrome

So from what i understand about this syndrome.
The patient is XY karotype. But appears phenotypically as a normal female. They have a blind ended vaginal pouch without a uterus. So from what I can understand this is because the SRY gene from the Y chromosome inhibits the mullierian (paramesonephric ducts). So no internal structures.

But why the external phenotype. They can't secrete estrogens either???
Confused with external phenotype...
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Old 07-02-2012
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Hey, firstly in androgen insensitivity syndrome androgen receptors are even if testosterone is produced it cannot act on its receptors to produce its effects...during enbryogenesis mullerian structures inhi by MIF mullerian inhib factor produced by sertoli cells...but dev of male ext genitalia dep upon all male fetuses ext genitalia are female before production of dht..and also struct like sem ves, vas def are dev in d presence of testosterone..since testosterone and dht cant act on their receptors..fetus phenotype remains female..coming to these pts some of androgens converted into estrogens by aromatase...
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The above post was thanked by:
SOBE223 (07-02-2012)


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