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Old 07-04-2012
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Question Pulmonary hypertension: Diagnosis & Treatment

A 45-year-old female presents to your office at 5pm o'clock with progressive exertional dyspnea. Her BMI 23Kg/m2, with familial history maternal death of primary pulmonary hypertension at age 38. In the patient lungs you observe a clear auscultation without wheezes or crackles. A loud heart sound at the left upper sternal border, the lungs are clear on chest with right axis deviation in EKG and with a measurement equal to 27 mmHg.

Item 1: If the patient's condition is genetic, which following protein should be present an abnormality in him?

A) Inactivation of P21 ras hyperactivation oncoprotein
B) Inactivation of α1-antitrypsin
C) Inactivation of bone morphogenetic protein receptor type II
D) Inactivation of Polycystin-1 encode protein
E) Mutation of TS1 or TS2


Item 2: You decide to send the patient home with a drug which will help him with this issue. This drug has which of the following mechanism of action?

A) Removes excess sputum
B) Inhibits the PGI2 receptor
C) Relaxes bronchial smooth muscle
D) Antagonizes endothelin-1 receptors
E) Inactivate NF-κB and the transcription factor


Sorry, forum I got more than 1 month without posting important question. So, remember the rule to post your reference answering it. The item 1 is in UW and the 2nd was................you know what that mean!!!!!!!!!!!!!!

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Last edited by alfjof; 07-04-2012 at 12:14 PM.
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Old 07-04-2012
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Quote:
Originally Posted by alfjof View Post

Item 1: If the patient's condition is genetic, which following protein should be present an abnormality in him?

A) Inactivation of P21 ras hyperactivation oncoprotein
B) Inactivation of α1-antitrypsin
C) Inactivation of bone morphogenetic protein receptor type II
D) Inactivation of Polycystin-1 encode protein
E) Mutation of TS1 or TS2


Item 2: You decide to send the patient home with a drug which will help him with this issue. This drug has which of the following mechanism of action?

A) Removes excess sputum
B) Inhibits the PGI2 receptor
C) Relaxes bronchial smooth muscle
D) Antagonizes endothelin-1 receptors
E) Inactivate NF-κB and the transcription factor

I think

i assume i've seen it in Robbins

Last edited by beka-CTS; 07-04-2012 at 12:32 PM.
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Old 07-04-2012
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this is easy C and D....the first one has to do with primary pulmonary hypertension

-the second one is referring to Bosentan, a drug that antagonizes endothelin receptors
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Old 07-04-2012
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1. C. BMP2R mutation(a type of TGF receptor).
2. D. Bosentan(Endothelin receptor antagonist).
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