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Old 06-28-2010
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Drug Leukopenia Side Effect

A 27 year old female is brought into the Emergency Department by her parents. The parents say she was chasing her favorite cat around the house trying to kill it with a butcher knife. The psychiatric resident on call asks the patient why she was doing this. She responds, “Because the demons told me too”. On further investigation the resident finds out she has a long history of visual and auditory hallucinations, that have been refractory to 3 different anti-psychotic medications. The patient is admitted to the hospital and started on a new medication. Two months after admission her hallucinations have ceased, but a routine CBC reveals marked leukopenia with the greatest depletion of polymorphonuclear leukocytes. What drug was this patient started on?
A - Heloperidol
B - Clozapine
C - Risperdone
D - Olanzapine
E - Chlorpromazine
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Old 06-28-2010
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B- Clozapine (causes agranulocytosis)
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Old 06-28-2010
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B - Clozapine
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Old 06-28-2010
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B. clozapine
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Old 06-29-2010
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clozapine, ticlopidine, sulphasalazine and antithyroid drugs cause agranulocytopenia....
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