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Old 07-12-2012
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Question Antibodies against intracellular components

We all know diseases associated with anti-dsDNA antibodies, anti-SS-A, antihistone and other autoantibodies.
I know these association too but I do not fully understand the whole mechanism. I know that a protein can't enter into a cell and antibodies are proteins.
So at the first how they could be preformed and the second how they can react with their intracellular targets?
Instead of saying “we don’t know why,” though, say “idiopathic.” It sounds so much smarter.
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Old 07-12-2012
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