Gilbert's syndrome; Stress Jaundice! - USMLE Forums
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Old 07-16-2012
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Liver Gilbert's syndrome; Stress Jaundice!

What is the pathophysiology behind the appearance of jaundice during periods of stress and infections in patients with Gilbert Syndrome!
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Old 07-16-2012
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Itll cause the patient to go jaundice because the UDP-glucoronyl transferase enzyme in the hapatocyte has become saturated. Gilberts patients have low UDP-glucornyl transferase enzyme.

So basically theres a backup in unconjugated bilirubin waiting to be glucuronidated.
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Old 07-16-2012
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I understand that. I guess my question is why is there hemolysis of rbc's during periods of stress and infection?
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Gastrointestinal-Tract-, Pathology-, Physiology-

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