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  #1  
Old 07-06-2010
Karrar's Avatar
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Zygote A confusing Sentence about Folate deficiency!!

In Folate deficiency there would be no neurological manifestations.

Is that true? if so then what about the symptoms of neural tube defects (i.e. Incontinence and leg paralysis associated with spina bifida) they r neurological manifestations, arn't they?
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Old 07-06-2010
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Info That's in the fetus not in others

Folate deficiency in the preconception female is a risk factor for developing neural tube defects in her fetus not in her body. This is because folate is needed to build new cells in the baby during organogensis.

The fetus is a special situation and you cannot take it for others. For examples if the fetus is subjected to lithium you'll have ebstein's anomaly while if you give lithium to any other you won't have this effect.

While in the adult or even in children or any age other than the fetus you don't have neurologic sequalae. So that statement you mentioned is correct.

B12 deficiency on the other hand is a cause of neurologic problems because the increased methylmalonate and the decreased succinyl co A affected neuronal myelination.
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Old 07-06-2010
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Info Folate and neurological symptoms

Then if we said that:
Lithium does not cause Ebstein's anomaly, this would be wrong statement I think..

It's the same if we said that: In Folate deficiency there would be no neurological manifestations.

I'm not fully convinced yet!!
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Old 07-06-2010
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Unhappy Please post the original question or paragraph

I remember such question in Kaplan or UW, in that question there were two options B12 and folate. You have to pick B12 as a cause of neurologic problems not folate.

If you can post the question exactly as you have seen it or the whole paragraph that you have read about this then we can discuss it better.

Right now your confusion is vague and we cannot take it further.
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Old 07-06-2010
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Quote:
Originally Posted by Karrar View Post
In Folate deficiency there would be no neurological manifestations.

Is that true? if so then what about the symptoms of neural tube defects (i.e. Incontinence and leg paralysis associated with spina bifida) they r neurological manifestations, arn't they?
When they say ,no neurological manifestations ,they dont talk about complications .U ll agree with me that all the signs you describe are not the mother's.The neurological effects are found in B12 bc it s required as a cofactor in formation of Succinyl CoA from methylmalonyl CoA.So ,the generation of odd-chained fatty acids, resulting from the deficit of succinyl-CoA may get incorporated into the myelin resulting in neurological syndrome of Vitamin B-12 deficiency.Folate doesnt interfere at all in that kind of reaction
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Old 07-07-2010
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Help

Quote:
Originally Posted by laithbv View Post
I remember such question in Kaplan or UW, in that question there were two options B12 and folate. You have to pick B12 as a cause of neurologic problems not folate.

If you can post the question exactly as you have seen it or the whole paragraph that you have read about this then we can discuss it better.

Right now your confusion is vague and we cannot take it further.
I saw before the Q you mentioned Laith, it was very easy..
This Q was in a TRUE/FALSE box (I don't remember the other statements but they were extremely easy). It was:


T/F Regarding folic acid the following statements are true:

1. ???
2. ???
3. In Folate deficiency there would be no neurological manifestations.
4. ???


If you face such a statement would you regard it TRUE?
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  #7  
Old 07-07-2010
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Quote:
Originally Posted by Karrar View Post
I saw before the Q you mentioned Laith, it was very easy..
This Q was in a TRUE/FALSE box (I don't remember the other statements but they were extremely easy). It was:


T/F Regarding folic acid the following statements are true:

1. ???
2. ???
3. In Folate deficiency there would be no neurological manifestations.
4. ???


If you face such a statement would you regard it TRUE?
What are the other options! If they are all absolutely wrong then yes option 3 is your best true answer.
In USMLE you have to play it smart. Sometimes you need to work by process of elimination.
USMLE no longer birng true or false statements. You have to choose only one answer.
Again, you did not put the question that confused you. If you put it exactly as it was shown to you then we can seriously discuss this matter.
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