Difference between Type II and Type III Hypersensitivity - USMLE Forums
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Old 07-20-2012
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Immunology Difference between Type II and Type III Hypersensitivity

Hi guys,

I'm having difficulty getting my head around the difference between Type II and Type III hypersensitivities. My very basic understanding is type two is ab mediated and type III is ab-ag mediated.

Can you explain how SLE and PAN are examples of Type III hypersensitivity and not type II?
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Type 2 is kinda like a sniper in action. You've got a set target and you're sending a hitman(Ig) to do the damage...targeted damage, to targeted tissues! For example in goodpasture we just have kidney and lung involvement, nothing else.

Type 3 on the other hand is carpet bombing. Your have immune complexes flying all over the place, activating complement and causing inflammation, and coagulation cascade activation and what not. the inflammation can happen pretty much anywhere where immune complexes go. And isn't that what happens in SLE?
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Thanks smanthrav...that makes sense.

do you get systemic deposition of the anti-dsDNA ab-ag complexes in SLE?? i suppose thats where i'm confused
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Quote:
Originally Posted by ChristopherJames View Post
Thanks smanthrav...that makes sense.

do you get systemic deposition of the anti-dsDNA ab-ag complexes in SLE?? i suppose thats where i'm confused
Yes you do. That's what causes all the inflammation.
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In type 2 antibodies attack on fixed antigen
In type 3 antigen & antibodies circulate all over body
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