Karyotype of the Partial Hydatiform Mole! - USMLE Forums
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Old 07-22-2012
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ObGyn Karyotype of the Partial Hydatiform Mole!

A 34-year-old primigravida woman was referred for ultrasonography examination at 16 weeks of gestation because of an elevated maternal serum alpha-fetoprotein (MSAFP) (3.5 multiples of the appropriate gestational median [MoM]). Serum β-hCG (human chorionic gonadotropin) was 240,000 mL/mL. Sonography revealed a viable fetus, 2 weeks smaller than well-documented gestational age. No anomalies were visible, and amniotic fluid was normal. The placenta was enlarged and had a molar appearance. Ten days later, the fetus spontaneously aborted. The placenta had a hydropic appearance, and the fetus was diagnosed as a partial hydatidiform mole. What karyotype finding supports this diagnosis?

a) 46 chromosomes, all of maternal origin
b) 46 chromosomes; 23 of paternal origin and 23 of maternal origin
c) 46 chromosomes, all of paternal origin
d) 69 chromosomes; 23 of paternal origin and 46 of maternal origin
e) 69 chromosomes; 46 of paternal origin and 23 of maternal origin
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Old 07-22-2012
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Matched!!!
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Old 07-22-2012
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Eee...69XXY
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Old 07-27-2012
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yup, it is e) 69 chromosomes; 46 of paternal origin and 23 of maternal origin
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Old 08-17-2012
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Old 08-17-2012
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69 chromosomes; 46 of paternal origin and 23 of maternal origin

One normal Ovum kariotype + 2 sperms (or one sperm that dublicates it's genome)
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