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Old 07-22-2012
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Immunology Immunodeficiency and GI Biopsy

A 6-month-old boy suffered from recurrent high-grade fever and diarrhea. He also had evidence of pneumonia. He showed only partial response to antibiotic therapy. An underlying immune deficiency was suspected. Serum electrophoresis showed severe hypogammaglobulinemia. Imaging studies revealed a normal thymus. The lymphocyte count in the peripheral blood film was within normal range. An intestinal biopsy was performed to further investigate the immune system and to look for a possible cause for diarrhea. The biopsy is likely to show which condition?

a) Absence of lymphocytes
b) Absence of Peyer patches
c) Absence of plasma cells
d) Prominent germinal centers
e) Villous atrophy
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Old 07-22-2012
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C. IgA def
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Old 07-22-2012
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Old 07-27-2012
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Default correct answer :)

correct answer is C) Plasma cells

This child has selective B cell deficiency. Bruton disease is the most common condition producing this deficiency at this age. Bruton disease has arrested development of B cells at the pre–B stage. Plasma cells are absent throughout the body in Bruton disease. There is a basic failure of pre–B cells to mature into B cells.
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