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Old 07-30-2012
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Drug Which drug would reduce methotrexate toxicity?

An 18-year-old woman who underwent surgery for osteogenic carcinoma is to begin postsurgical chemotherapy with high-dose methotrexate (MTX). After the completion of the MTX infusion, administration of which drug would most likely reduce the MTX-induced toxicity to normal cells?

a) Amifostine
b) Dexrazoxane
c) Dihydrofolic acid
d) Leucovorin
e) Mesna
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Old 07-30-2012
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D leucovorin(folinic acid) rescue
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Go with D
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d) Leucovorin or Folinic acid
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Old 07-30-2012
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D...........
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Old 07-30-2012
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D it is.............
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Old 07-31-2012
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Correct Answer correct answer :)

The answer is d) Leucovorin

Leucovorin is also called citrovorum factor or 5-formyl-tetrahydrofolic acid. It is an active derivative of folic acid, and as a "one-carbon" donor, it does not require reduction by dihydrofolate reductase (DHFR). Leucovorin is a cytoprotective agent used to counteract the bone marrow suppression that occurs with high-dose MTX treatment. Leucovorin is taken up by host cells but not cancer cells. Thus, the host cells are "rescued."
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Old 08-01-2012
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Quote:
Originally Posted by Casandra View Post
The answer is d) Leucovorin

Leucovorin is also called citrovorum factor or 5-formyl-tetrahydrofolic acid. It is an active derivative of folic acid, and as a "one-carbon" donor, it does not require reduction by dihydrofolate reductase (DHFR). Leucovorin is a cytoprotective agent used to counteract the bone marrow suppression that occurs with high-dose MTX treatment. Leucovorin is taken up by host cells but not cancer cells. Thus, the host cells are "rescued."
love all of the questions that u post but this one was comparatively easier.
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Old 08-02-2012
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Quote:
Originally Posted by kdm0101 View Post
love all of the questions that u post but this one was comparativly easier.
well some questions are for integrating ideas - bit more difficult and some just serve as a remainders - easier but also useful sometimes
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Old 08-02-2012
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Default D

(D)

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