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Old 08-01-2012
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Liver Liver Zone susceptible to toxic injury!

which liver zone is most susceptible to
toxic injury?
ischaemic injury?

kaplan and first aid have diff. answers to this ques.im confused which is correct
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Old 08-01-2012
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Ischeamic injury is peripheral zone
Toxic injury central zone
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Old 08-01-2012
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Don't know about toxic zone but less oxygen I central vein zone right? So central zone will be more prone to ischemia.
For toxic zone I think portal vein surrounded area would be affected but not sure.
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thanks guys.
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Old 08-01-2012
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I read somewhere that even around the central vein the cells closest to the central vein receive more oxygen so less susceptible to damage compared to those around the central vein but in the periphery . I think it was in Goljan RR cell injury chapter. Hope that helps


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Old 08-01-2012
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Don't know about toxic zone cause even intravenously injected toxins can harm the liver but if ingested then I guess it should be the cells around portal vein


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Old 08-02-2012
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Default confused

why does FA pg 342 2012 edition say centrilobular ( zone 3 ) susceptible yo coth toxic and ischemic injury???
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Old 08-02-2012
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I remember that its the area around the portal vein for both forms of injury.
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Old 08-02-2012
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Yes zone 3 is most susectiple to both tyes of injury toxic and ischemic. Ischemic becz zone 3 receives less blood supply than the peripheral zone which is close to the hepatic artery. Also toxic materials wash from zone 3 is less becz of this lower blood supply.
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