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Old 08-01-2012
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Bones Intramembranous Ossification Bone!

Achondroplasia, which is the most common cause of nonlethal dwarfism, produces a disturbance in endochondral ossification due to a mutation in the FGFR3 gene. Which of the following bones forms predominantly by intramembranous ossification and would be largely unaffected in a patient with achondroplasia?

a) Femur
b) Mandible
c) Occipital bone
d) Radius
e) Vertebrae
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Old 08-01-2012
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The answer is C.
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Old 08-01-2012
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answer is C
achondroplasia -failure of longitudinal bone growth,endochondral ossification-short limb,membranous ossification is not affected-normal sized head and vertebral column (head large than limbs rather than being large in a absolute sense)normal growth hormone and insulin growth factor-1 level
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Old 08-01-2012
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C...all the way
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Old 08-02-2012
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Correct Answer correct answer :)

yeah, I marked occipital bone too but unfortunatelly it wasn't the right answer...

The answer is b) Mandible

The mandible forms mainly by intramembranous ossification around Meckel’s cartilage and is often prominent in achondroplasia.

As for the occipital bone - Except for its upper (interparietal) portion, the occipital bone forms by endochondral ossification around the foramen magnum, which may be dangerously stenosed in achondroplasia.
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Old 08-02-2012
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that's interesting, i thought it was the vertebra.
is there a list of the membraneous ossification bones? anybody? that would be awesome
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Histology-, Musculoskeletal-, Step-1-Questions, Syndromes-Acronyms

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