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Old 08-02-2012
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Question The cellular basis of this disease!

A 42-year-old woman presents to the clinic with the chief complaints of weight loss and fatigue. She has a rash on both cheeks that spreads across the nose. Urine analysis reveals both blood and protein in her urine, but she does not complain of dysuria. However, she says that her joints are painful, especially in her hands and wrists. What cellular processes would be expected to be impaired in this patient?

a) Degrading of extracellular products
b) Degrading prescribed medicines
c) Folding peptide chains into α-helices
d) Processing heterogenous nuclear RNA (hnRNA) transcripts
e) Processing proteins for extracellular secretion
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Old 08-02-2012
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Default D

SLE disease----anti SnRNP's antibodies(anti-smith Ab's)----defect in hnRNA/mRNA processing
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Old 08-03-2012
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Correct Answer correct answer :)

The answer is d) Processing heterogenous nuclear RNA (hnRNA) transcripts

The patient has systemic lupus erythematosus (SLE). This is an autoimmune disease in which the body produces autoantibodies to a variety of tissues. Because the antibodies can bind to many tissue types, a variety of clinical signs and symptoms are seen; however, the common ones are those observed in this patient. The antibodies are directed against ribosomal subunits, DNA–RNA hybrids, and small nuclear ribonucleoprotein particles (snRNPs); snRNPs are involved in splicing hnRNA transcripts, and autoantibody binding would prevent the snRNPs from functioning normally.
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Cell-Biology-, Immunology-, Molecular-Biology-, Pathology-, Step-1-Questions

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