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Old 08-03-2012
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Default Antiphospholipid antibody syndrome

hey all..
ny1 knws y u hv a prolongd PTT in d Antiphospholid antibody syndrome???..wat i read is dat d antibody inhibits t-PA activity necessary for trophoblast invasion of uterus n dats y u hv d recurrent spontaneous abortions asso wt dis syndrome..bt ny idea y d prolong PTT???
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Old 08-03-2012
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Hi, well as you can see it produces an antibody, as this antibody can bind membranes and the other stuff you mentioned it can also bind to the glass tube when you measure the aPTT, as you know or not the glass in the tube binds factor 12 and activates the intrinsic coagulation cascade, so if you catch those binding spaces with the antibodies the intrinsic pathway will take more time to get activated and thats the paradox although it shows prolonged aPTT, this people are actually suffering from hypercoagulable state.

Hope it was understandable.
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adeelsaleemi (08-04-2012), Linc (09-05-2015), Master shifu (08-04-2012), sruthi (08-04-2012)
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Old 08-04-2012
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Thanks a lot!!
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