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Old 07-16-2010
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Drug Beta blockers in the treatment of Pheochromocytoma!

I read that we should never give beta blockers in the treatment of pheochromocytoma.

I don't understand why

Can anybody explain for me please
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Default Beta blockers in the treatment of Pheochromocytoma!

The adrenaline and nor-adrenaline released by adrenal medula act on both alpha & beta receptors. So, beta blockers alone will be of no help. Also, the unopposed alpha receptor stimulation will cause Increased vasoconstriction, further worsening the hypertention.
So best strategy is to give an alpha blocker before giving beta blockers, in a pt of pheochromocytoma.


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Quote:
Originally Posted by doc_study View Post
The adrenaline and nor-adrenaline released by adrenal medula act on both alpha & beta receptors. So, beta blockers alone will be of no help. Also, the unopposed alpha receptor stimulation will cause Increased vasoconstriction, further worsening the hypertention.
So best strategy is to give an alpha blocker before giving beta blockers, in a pt of pheochromocytoma.


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Thank you,
But then why beta blockers are enough in essential hypertension?
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pheochromocytoma is bec of the excessive production of catecholamines

but in essential HTN u dont know the cause of HTN ,its mostly idiopathic , so if u give just beta blockers it will help unlike in pheochromocytoma where u see effects of both alpha and beta receptors
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