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Old 07-16-2010
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RBC swelling of erythrocytes

Mature erythrocytes taken from a patient with chronic anemia are placed in an isotonic, glucose-containing solution. The cells are observed to swell, then rupture. The erythrocytes actively uptake glucose. The addition of ATP to the solution prevents this phenomenon. If this is due to an autosomal recessive glycolytic enzyme deficiency, which enzyme is missing?
A. Phosphofructokinase-1
B. Glyceraldehyde phosphate dehydrogenase
C. Glucokinase
D. Pyruvate kinase
E. Hexokinase
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Old 07-16-2010
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It' definately "D" ... RBC can be osmotically fragile in case of pyruvate Kinase deficiencey.
RBC swell due to decrease Na/K pump & ion imbalance
While also, ATP correction indicates That RBC have anaerobic energy metabolism, and when Pyruvate kinase is defecient = No ATP produced at anaerobic metabolism. THis leads to hemolysis of the RBC in the spleen
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Old 07-16-2010
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Quote:
Originally Posted by Mohabravo View Post
It' definately "D" ... RBC can be osmotically fragile in case of pyruvate Kinase deficiencey.
RBC swell due to decrease Na/K pump & ion imbalance
While also, ATP correction indicates That RBC have anaerobic energy metabolism, and when Pyruvate kinase is defecient = No ATP produced at anaerobic metabolism. THis leads to hemolysis of the RBC in the spleen
B I N G O ...
ive read about this before but i cant find where now. can u pls tell me where i can find it in FA or kaplan (if u still remember)?

thx.
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Old 07-16-2010
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Find this in Kaplan / Biochemistry / Chapter of Gylcolysis
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Old 07-16-2010
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ive read about this before but i cant find where now. can u pls tell me where i can find it in FA or kaplan (if u still remember)?

thx.
Find it in kaplan/Biochemistry/glycolysis
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Old 07-17-2010
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Quote:
Originally Posted by Mohabravo View Post
It' definately "D" ... RBC can be osmotically fragile in case of pyruvate Kinase deficiencey.
RBC swell due to decrease Na/K pump & ion imbalance
While also, ATP correction indicates That RBC have anaerobic energy metabolism, and when Pyruvate kinase is defecient = No ATP produced at anaerobic metabolism. THis leads to hemolysis of the RBC in the spleen
B I N G O ...
nice,
i knew it but still answered wrong
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