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Old 08-04-2012
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Drug Drugs with Bronchomotor changes?

In the figure (see attachment), changes in bronchomotor tone are depicted in terms of constriction (+) or relaxation (-). The first panel of the figure (control) shows changes that were elicited by five different procedures (numbered 1 through 5), each of which was performed alone. The remaining panels show changes that were elicited by the same five procedures, each of which was performed after pretreatment with a different drug. Which is most likely procedure 5 in this experimental paradigm?

a) Administration of bethanechol
b) Administration of histamine
c) Administration of terbutaline
d) Stimulation of sympathetic nerves
e) Stimulation of the vagus nerve
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Old 08-04-2012
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its D........
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Old 08-05-2012
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B i guess
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Yup stimulation of sympathetic nerve
As it will have effect of beta blocker and cocaine will prevent NE reputable so more NE for stimulation.



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Old 08-05-2012
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read the y axis wrong so change my answer to D
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Default correct answer :)

The answer is d) Stimulation of sympathetic nerves

Sympathetic nerve stimulation causes bronchodilation by increasing circulating epinephrine. This response is blocked by propranolol and potentiated by cocaine. Cocaine blocks the uptake of epinephrine into the nerve terminal (uptake 1) and thereby prolongs the effects of epinephrine.
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But I was thinking can this prolonged release of Ne can desensitize receptors ? Or this just only happen in muscarinic receptors?


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Old 08-06-2012
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Quote:
Originally Posted by koolkiller88 View Post
But I was thinking can this prolonged release of Ne can desensitize receptors ? Or this just only happen in muscarinic receptors?
desensitization occurs with every receptor (M, alpha, beta etc.) if the exposure to the stimulant is prolonged.

but why are you asking about prolonged exposure? the question doesn't say anything about it...
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Originally Posted by Casandra View Post
desensitization occurs with every receptor (M, alpha, beta etc.) if the exposure to the stimulant is prolonged.

but why are you asking about prolonged exposure? the question doesn't say anything about it...
Ya i know, its just a doubt. I wanted to clear up. thanks
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Old 08-06-2012
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Why not c??
Just want to clear concept...
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Old 08-07-2012
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Why not c??
Just want to clear concept...
terbutaline is a beta2 agonist.
cocaine would indirectly increase NE levels -> NE doesn't work on beta2 rec + terbutaline is not taken up into the nerve terminal, so its effects are not potentiated by cocaine.
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Old 08-07-2012
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can you explain what happen in panel 2 and 3? thanks
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