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Diagnosis of EBV infection?

5K views 23 replies 9 participants last post by  vita86 
#1 ·
Which of the following procedures or clinical signs is most specific for the diagnosis of infectious mononucleosis caused by the Epstein-Barr virus?
A. Laboratory diagnosis is based on the presence of "atypical lymphocytes" and EBV-specific antibody
B. Growth in tissue culture cells
C. Heterophile antibodies in serum
D. Lymphadenopathy and splenomegaly on physical examination
E. B-cell lymphocyte proliferation
 
#7 ·
heyy i found it

Contact with infected secretions such as saliva can result in infection with EBV, thus the term kissing disease. Laboratory diagnosis of EBV-induced infectious mononucleosis is usually determined by presence of atypical lymphocytes, heterophile antibodies, or specific antiviral antibodies such as VCA (viral capsid antibody).
 
#8 ·
heyy i found it

Contact with infected secretions such as saliva can result in infection with EBV, thus the term kissing disease. Laboratory diagnosis of EBV-induced infectious mononucleosis is usually determined by presence of atypical lymphocytes, heterophile antibodies, or specific antiviral antibodies such as VCA (viral capsid antibody).
but the explanation points to A or C. they said it is B?:confused:
 
#15 ·
monospot test (heterophile antibodies) can also be positive in people with lymphoma, systemic lupus erythematosus (lupus), and some gastrointestinal cancers, although it is not used as a diagnostic or screening tool for these conditions. negative monospot test with same clinical scenario as EBV suggests CMV...
 
#16 ·
the article talks about IgM specific for EBV. n that is what a heterophile antibody is. i understand how atypical lymphocytes also points towards kissing disease, but in kaplan, the diagnosis of kissing disease is made by finding of heterophile antibody finding. atypical lymphocytes is not specific.
 
#18 ·
@seetal thats y i answered it as C

any seniors who can clear this doubt
thanks in advance
i also leaned towards C at the instant i read the question, bkz all qbanks wen ask such a question they point towards heterophile antibodies, then i googled up so find this article... so i thot ok A is the answer... now its confusing really:notsure:
 
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#21 ·
Which of the following procedures or clinical signs is most specific for the diagnosis of infectious mononucleosis caused by the Epstein-Barr virus?
A. Laboratory diagnosis is based on the presence of "atypical lymphocytes" and EBV-specific antibody
B. Growth in tissue culture cells
C. Heterophile antibodies in serum
D. Lymphadenopathy and splenomegaly on physical examination
E. B-cell lymphocyte proliferation
so guys which one is it? i want to say C or A haha
 
#24 ·
CMV : can be grown in Fibroblast culture + PCR to detect antigen

EBV : atypical lymphocyte +hetrophile antibody + igM to VCA (viral caspid antigen)

so i guess its A:notsure:??

cuz many virus can cause atypical lymphocyte n Cmv gets +ive for hetrophile antibody aswel (correct me if i am wrong) i dun remmber exactly

so answer is A?
 
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