Which of the following procedures or clinical signs is most specific for the diagnosis of infectious mononucleosis caused by the Epstein-Barr virus?
A. Laboratory diagnosis is based on the presence of "atypical lymphocytes" and EBV-specific antibody
B. Growth in tissue culture cells
C. Heterophile antibodies in serum
D. Lymphadenopathy and splenomegaly on physical examination
E. B-cell lymphocyte proliferation
Contact with infected secretions such as saliva can result in infection with EBV, thus the term kissing disease. Laboratory diagnosis of EBV-induced infectious mononucleosis is usually determined by presence of atypical lymphocytes, heterophile antibodies, or specific antiviral antibodies such as VCA (viral capsid antibody).
Contact with infected secretions such as saliva can result in infection with EBV, thus the term kissing disease. Laboratory diagnosis of EBV-induced infectious mononucleosis is usually determined by presence of atypical lymphocytes, heterophile antibodies, or specific antiviral antibodies such as VCA (viral capsid antibody).
same here. sometimes they have misprints. like they can answer is E but all the explanation points to A. it happens in kaplan q book n FA q book too sometimes.
monospot test (heterophile antibodies) can also be positive in people with lymphoma, systemic lupus erythematosus (lupus), and some gastrointestinal cancers, although it is not used as a diagnostic or screening tool for these conditions. negative monospot test with same clinical scenario as EBV suggests CMV...
the article talks about IgM specific for EBV. n that is what a heterophile antibody is. i understand how atypical lymphocytes also points towards kissing disease, but in kaplan, the diagnosis of kissing disease is made by finding of heterophile antibody finding. atypical lymphocytes is not specific.
i also leaned towards C at the instant i read the question, bkz all qbanks wen ask such a question they point towards heterophile antibodies, then i googled up so find this article... so i thot ok A is the answer... now its confusing really:notsure:
lol... u know guys, what's important is that we now know what's the FOR SURE answer. so whether it's A or C, they wont repeat this same question for out Exam, but at least we know if they ask heterophile positive we say mono, if they ask heterophile negative we say CMV. )
Which of the following procedures or clinical signs is most specific for the diagnosis of infectious mononucleosis caused by the Epstein-Barr virus?
A. Laboratory diagnosis is based on the presence of "atypical lymphocytes" and EBV-specific antibody
B. Growth in tissue culture cells
C. Heterophile antibodies in serum
D. Lymphadenopathy and splenomegaly on physical examination
E. B-cell lymphocyte proliferation
hey , i think B is the right ..... the most specific is that rulesout others ....culture of virus is the most specific , , ( after that it can be be detected by pcr/southernblot ,,,,,
cuz many virus can cause atypical lymphocyte n Cmv gets +ive for hetrophile antibody aswel (correct me if i am wrong) i dun remmber exactly
so answer is A?
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