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  #1  
Old 07-16-2010
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Virus Diagnosis of EBV infection?

Which of the following procedures or clinical signs is most specific for the diagnosis of infectious mononucleosis caused by the Epstein-Barr virus?
A. Laboratory diagnosis is based on the presence of "atypical lymphocytes" and EBV-specific antibody
B. Growth in tissue culture cells
C. Heterophile antibodies in serum
D. Lymphadenopathy and splenomegaly on physical examination
E. B-cell lymphocyte proliferation
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  #2  
Old 07-16-2010
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hmm.. i keep looking at A or C. but i think ill go with C.
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Old 07-16-2010
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i thought its C
but they gave answer as B in the files u sent me
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Quote:
Originally Posted by ecgram View Post
i thought its C
but they gave answer as B in the files u sent me
say what!!
what was the explanation? i havent done microbiology (only pharmacology so far n a little pathology)
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  #5  
Old 07-16-2010
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hmmm sorry i didnt understand the explanation there and i forgot in which document the questions was its in either micro2 or 3 from the files u sent
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Quote:
Originally Posted by ecgram View Post
hmmm sorry i didnt understand the explanation there and i forgot in which document the questions was its in either micro2 or 3 from the files u sent
ok no worries. ill go look for it tonight n post it up. this is a shocker question n answer btw.
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Old 07-16-2010
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heyy i found it

Contact with infected secretions such as saliva can result in infection with EBV, thus the term kissing disease. Laboratory diagnosis of EBV-induced infectious mononucleosis is usually determined by presence of atypical lymphocytes, heterophile antibodies, or specific antiviral antibodies such as VCA (viral capsid antibody).
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Quote:
Originally Posted by ecgram View Post
heyy i found it

Contact with infected secretions such as saliva can result in infection with EBV, thus the term kissing disease. Laboratory diagnosis of EBV-induced infectious mononucleosis is usually determined by presence of atypical lymphocytes, heterophile antibodies, or specific antiviral antibodies such as VCA (viral capsid antibody).
but the explanation points to A or C. they said it is B?
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  #9  
Old 07-16-2010
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i think its C
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Quote:
Originally Posted by ecgram View Post
i think its C
same here. sometimes they have misprints. like they can answer is E but all the explanation points to A. it happens in kaplan q book n FA q book too sometimes.
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  #11  
Old 07-16-2010
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Quote:
Originally Posted by ecgram View Post
hmmm sorry i didnt understand the explanation there and i forgot in which document the questions was its in either micro2 or 3 from the files u sent

the answer is definitely A: read this article

http://www.ncbi.nlm.nih.gov/pubmed/390371
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Old 07-16-2010
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I'd argue for A too - wouldn't having antibodies for something pretty much make it specific for it?
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The article seems to confirm it, thanks DoctorF
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Old 07-17-2010
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what are the other diseases/infections which are also heterophile antibody positive again? i remember reading about it before...
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Old 07-17-2010
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monospot test (heterophile antibodies) can also be positive in people with lymphoma, systemic lupus erythematosus (lupus), and some gastrointestinal cancers, although it is not used as a diagnostic or screening tool for these conditions. negative monospot test with same clinical scenario as EBV suggests CMV...
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Old 07-17-2010
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the article talks about IgM specific for EBV. n that is what a heterophile antibody is. i understand how atypical lymphocytes also points towards kissing disease, but in kaplan, the diagnosis of kissing disease is made by finding of heterophile antibody finding. atypical lymphocytes is not specific.
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Old 07-18-2010
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@seetal thats y i answered it as C

any seniors who can clear this doubt
thanks in advance
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Old 07-18-2010
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Quote:
Originally Posted by ecgram View Post
@seetal thats y i answered it as C

any seniors who can clear this doubt
thanks in advance
i also leaned towards C at the instant i read the question, bkz all qbanks wen ask such a question they point towards heterophile antibodies, then i googled up so find this article... so i thot ok A is the answer... now its confusing really
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Old 07-18-2010
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actually it is confusing but most of the question banks they refer to heterophile antibodies so lets go with that answer
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Quote:
Originally Posted by ecgram View Post
actually it is confusing but most of the question banks they refer to heterophile antibodies so lets go with that answer

lol... u know guys, what's important is that we now know what's the FOR SURE answer. so whether it's A or C, they wont repeat this same question for out Exam, but at least we know if they ask heterophile positive we say mono, if they ask heterophile negative we say CMV.
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Old 08-04-2013
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Quote:
Originally Posted by ecgram View Post
Which of the following procedures or clinical signs is most specific for the diagnosis of infectious mononucleosis caused by the Epstein-Barr virus?
A. Laboratory diagnosis is based on the presence of "atypical lymphocytes" and EBV-specific antibody
B. Growth in tissue culture cells
C. Heterophile antibodies in serum
D. Lymphadenopathy and splenomegaly on physical examination
E. B-cell lymphocyte proliferation

so guys which one is it? i want to say C or A haha
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  #22  
Old 08-05-2013
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Most specific - C, most sensitive - D
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  #23  
Old 08-10-2013
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I agree

hey , i think B is the right ..... the most specific is that rulesout others ....culture of virus is the most specific , , ( after that it can be be detected by pcr/southernblot ,,,,,
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Quote:
Originally Posted by dr mumble View Post
hey , i think B is the right ..... the most specific is that rulesout others ....culture of virus is the most specific , , ( after that it can be be detected by pcr/southernblot ,,,,,
CMV : can be grown in Fibroblast culture + PCR to detect antigen

EBV : atypical lymphocyte +hetrophile antibody + igM to VCA (viral caspid antigen)

so i guess its A??

cuz many virus can cause atypical lymphocyte n Cmv gets +ive for hetrophile antibody aswel (correct me if i am wrong) i dun remmber exactly

so answer is A?
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