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Old 08-06-2012
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Default Which drug would inhibit metabolism of diazepam?

A 24-year-old woman begins treatment with diazepam to control anxiety. She is also taking an antidepressant medication. Which of the following antidepressants would enhance the actions of diazepam in this patient by inhibiting its metabolism?

a) Bupropion
b) Fluoxetine
c) Mirtazapine
d) Trazodone
e) Venlafaxine
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Old 08-06-2012
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Default B. fluoxetine

The answer would be "FLUOXETINE" due to same old concept. Fluoxetine is inhibitor of CYP2C19 (cytochome P450 enzyme)

Do we have to remember every single inhibitor or inhibitor of CYP 450?
Because its inhibiting effect in to even mentioned in FA common CYP450 inducers and inhibitors.
Or is just keep on learning or try to remember as many as you come across.

Saw this information while searching about this question in medscape.
Diazepam + Mirtazapine both increases sedation together.
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Old 08-07-2012
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Default correct answer

The answer is b) Fluoxetine

Diazepam is metabolized by both CYP2C19 and CYP3A4. Therapeutic doses of fluoxetine impair both of these pathways.
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