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Old 08-10-2012
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Drug Calculate the Drug Half Life?

a 70 yr old man is treated with a new antifungal drug for fungal sepsis..the drug is actively secreted by kidney and has volume of distribution of 35 litres and clearance of 690ml/min...the half life of drug(in min) is closest to which of the following..?
a) 15
b) 35
c) 65
d) 105
e) 125

when i calculated i got 35 as an answer..but when i refer the key it gave as 15...please explain..?.. thank you
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Old 08-10-2012
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If you got that answer from the nbme 6 the right answer is 35 not 15.
t 1/2 = 0.7 x vd/ cl
35=0.7x 35000ml/690 ml/min

the only change you should do is the liters of vd to ml
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The above post was thanked by:
Doc4Step1 (08-10-2012), meanmr.mustard (08-10-2012), venky2600 (08-10-2012)


Pharmacology-, Step-1-Questions

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