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Old 08-13-2012
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Smile inhalational anaesthetic doubt!!

i read dat an inhalational anesthetic wt a high arteriovenous concentratn gradient soon aftr beginnnin inhalatn has a slow onset of action..explanatn givn was cz of d high tissue solubility, dre is high tissue uptake wich leads to d high av gradient..n d slow onset of action is cz more gas is needed to saturate d tissues..

bt i dont get dat!! if dres high tissue uptake, shoudnt d effects on d tissues b sooner too??

it wud b rly helpful if someone cud xplain dis to me!! tnx in advance
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Old 08-13-2012
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Well, if you're putting anaesthetic into your fat and muscles, its going to take more time before you can reach a level high enough for it to produce the required anaesthetic effect, right?
If a gas doesn't dissolve in tissues all that much, then its blood levels can go up much faster, since there's no need to fill up the tissues first.
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Old 08-13-2012
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Quote:
Originally Posted by sruthi View Post

bt i dont get dat!! if dres high tissue uptake, shoudnt d effects on d tissues b sooner too??
anaesthetics do not work in tissue , so more uptake longer the time for min effective coc in blood
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