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Old 08-22-2012
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Heart Vascular compression in which phase of cardiac cycle?

A 48-year-old man with a history of hypertrophic cardiomyopathy experiences exercise-induced angina even though he has no clinical evidence of coronary artery disease. This patient's anginal symptoms could be partially explained by coronary vascular compression during which phase or division of the cardiac cycle?

a) Atrial systole
b) Isovolumetric ventricular relaxation
c) Rapid ventricular filling
d) Slow ventricular filling (diastasis)
e) Ventricular systole
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Old 08-22-2012
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Would be E
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Old 08-23-2012
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E. Ventricular systole-->contraction of muscle fibres forces the vessel lumen shut.
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Old 08-23-2012
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Default correct answer :)

The answer is e) Ventricular systole

Even in a healthy human subject with a normal heart, ventricular wall tension during systole is high enough to compress the intramural vessels and decrease perfusion to the ventricular muscle. In a patient with hypertrophic cardiomyopathy, this mismatch between energy demand and coronary blood flow would be increased, and can be associated with myocardial ischemia.
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