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Old 08-23-2012
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Question translocation factor

q) EWS-FL-1 , a t (11:22) translocation product is ------?

A) a constitutively active tyrosine kinase
b) a pro-angiogenic factor
c) a nuclear receptor
d) an immunoglobulin
e) an overactive transcription factor
f) an antiapoptotic factor
g) an acid phosphatase
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Old 08-23-2012
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Default my answer

e) an overactive transcription factor ?
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Old 08-23-2012
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Is it E . transcription factor???
I really dont remeber reading such thing ,Goljan didnt mention this i think or was my poor prep!.. Plz give the answer..
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Old 08-23-2012
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yes, the right one is e) transcrption factor-----t(11: 22) is translocation in ewing's sarcoma

as for the other options....a) active tyrosine kinase------CML---t(9:22)
b) a pro angiogenic factor------ in neoplastic growth of VEGF
c)a nuclear receptor----AML-M3----PML-RAR alpha fusion( t(15:17)
d) an immunoglobulin-----multiple myeloma--igG
f)an antiapoptotic--------follicular lymphoma-----bcl2 t(14:18)
g) acid phosphatase-------------prostate carcinoma----prostatic acid phosphatase



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Originally Posted by dr.nitowl View Post
Is it E . transcription factor???
I really dont remeber reading such thing ,Goljan didnt mention this i think or was my poor prep!.. Plz give the answer..
and as for the question is concerned..it's not mentioned in goljan or FA.....but ,i don't think this as much high yield to know......these forums are not for assessment just for elaborating your knowledge.....so dn't get discouraged dude........good luck
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