Belindalimm Daily Questions: Biochemistry #1 - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 08-23-2012
USMLE Forums Veteran
 
Steps History: 1+CK+CS
Posts: 207
Threads: 68
Thanked 85 Times in 57 Posts
Reputation: 95
Arrow Belindalimm Daily Questions: Biochemistry #1

A 2-month-old boy with mildly dysmorphic features is brought to the emergency department after having a brief generalized seizure, which left him semi comatose. Laboratory studies show elevated C8-C10 acylcarnitines. Which of the following additional findings is most likely in this patient?

A. Decreased secretion of glucagon
B. decreased plasma free fatty acids
C. Hyperammonemia
D. Hyperglycemia
E. Hyperketosis
Reply With Quote Quick reply to this message
The above post was thanked by:
sruthi (08-23-2012)



  #2  
Old 08-23-2012
koolkiller88's Avatar
USMLE Forums Master
 
Steps History: Step 1 Only
Posts: 864
Threads: 62
Thanked 374 Times in 225 Posts
Reputation: 384
Default C. hyperammonemia

Thanks for question. It made me to review MCAD and CAT deficiency.
I think this child have Medium chain acyl-Co A dehydrogenase deficiency (MCAD)
in this disease hepatic beta oxidation of fatty acid is impaired.

A. Decreased secretion of glucagon- Due to hypoglycemia there would be increased secretion of glycogen.
B. decreased plasma free fatty acids- As beta oxidation is impaired then i think free fatty acid will increase.
C. Hyperammonemia- only left option , i think impaired beta oxidation can cause accumulation of substrate in liver, which can lead to impaired liver function. So decrease metabolism of ammonia.
D. Hyperglycemia- In MCAD hypoglcemia
E. Hyperketosis- In MCAD hypoketosis
__________________
One day i will infect these microbes and they will search for "Anti-MEbiotic"....
To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts.
Reply With Quote Quick reply to this message
  #3  
Old 08-23-2012
USMLE Forums Veteran
 
Steps History: 1+CK+CS
Posts: 207
Threads: 68
Thanked 85 Times in 57 Posts
Reputation: 95
Default

Quote:
Originally Posted by koolkiller88 View Post
Thanks for question. It made me to review MCAD and CAT deficiency.
I think this child have Medium chain acyl-Co A dehydrogenase deficiency (MCAD)
in this disease hepatic beta oxidation of fatty acid is impaired.

A. Decreased secretion of glucagon- Due to hypoglycemia there would be increased secretion of glycogen.
B. decreased plasma free fatty acids- As beta oxidation is impaired then i think free fatty acid will increase.
C. Hyperammonemia- only left option , i think impaired beta oxidation can cause accumulation of substrate in liver, which can lead to impaired liver function. So decrease metabolism of ammonia.
D. Hyperglycemia- In MCAD hypoglcemia
E. Hyperketosis- In MCAD hypoketosis
Also failure in beta-oxidation of medium chain acyl-CoA leads to ATP deficiency, which hinders urea cycle in liver, finally causes hyperammonemia.
Reply With Quote Quick reply to this message



Reply

Tags
Biochemistry-, Step-1-Questions

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
Belindalimm Daily Questions: Biochemistry #4 belindalimm USMLE Step 1 Forum 10 09-30-2012 10:01 AM
Belindalimm Daily Questions: Microbiology #1 belindalimm USMLE Step 1 Forum 8 09-18-2012 03:42 AM
Belindalimm Daily Questions: Biochemistry #3 belindalimm USMLE Step 1 Forum 6 08-28-2012 07:45 AM
Belindalimm Daily Questions: Biochemistry #2 belindalimm USMLE Step 1 Forum 10 08-24-2012 04:01 AM
Belindalimm Daily Questions: Histology #1 belindalimm USMLE Step 1 Forum 8 08-22-2012 01:19 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)